HTLV-1, ATLL, severe hypercalcaemia and HIV-1 co-infection: an overview.
Pan Afr Med J
; 30: 61, 2018.
Article
em En
| MEDLINE
| ID: mdl-30344845
ABSTRACT
HIV and HTLV (Human T-ymphotropic Virus) are the only known retroviruses responsible for causing infection in humans. HTLV-1 and HIV-1 are frequent co-pathogens, however, despite its potential for accelerated progression of HIV disease and the risk of developing adult T-cell lymphoma/leukemia (ATLL), HTLV-1 is seldom considered for investigation in the HIV-1 positive individual. Severe/refractory hypercalcaemia, unresponsive to conventional calcium lowering therapy may complicate up to 70% of cases of ATLL. In addition, HTLV-1 and ATLL have both been associated with a rise in dysfunctional CD4 lymphocytes, thereby conveying a false sense of immune competence in the HIV-1 infected individual.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HTLV-I
/
Leucemia-Linfoma de Células T do Adulto
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Infecções por HIV
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Hipercalcemia
Limite:
Humans
Idioma:
En
Revista:
Pan Afr Med J
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
África do Sul