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Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome.
Xie, Stanley C; Gillett, David L; Spillman, Natalie J; Tsu, Christopher; Luth, Madeline R; Ottilie, Sabine; Duffy, Sandra; Gould, Alexandra E; Hales, Paul; Seager, Benjamin A; Charron, Carlie L; Bruzzese, Frank; Yang, Xiaofeng; Zhao, Xiansi; Huang, Shih-Chung; Hutton, Craig A; Burrows, Jeremy N; Winzeler, Elizabeth A; Avery, Vicky M; Dick, Lawrence R; Tilley, Leann.
Afiliação
  • Xie SC; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Melbourne , VIC 3010 , Australia.
  • Gillett DL; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Melbourne , VIC 3010 , Australia.
  • Spillman NJ; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Melbourne , VIC 3010 , Australia.
  • Tsu C; Oncology Clinical R&D , Takeda Pharmaceuticals International Co. , Cambridge , Massachusetts 02139 , United States.
  • Luth MR; Host-Microbe Systems and Therapeutics Division , UC San Diego School of Medicine , La Jolla , California 92093 , United States.
  • Ottilie S; Host-Microbe Systems and Therapeutics Division , UC San Diego School of Medicine , La Jolla , California 92093 , United States.
  • Duffy S; Griffith Institute for Drug Discovery , Griffith University , Brisbane , QLD 4111 , Australia.
  • Gould AE; Oncology Clinical R&D , Takeda Pharmaceuticals International Co. , Cambridge , Massachusetts 02139 , United States.
  • Hales P; Oncology Clinical R&D , Takeda Pharmaceuticals International Co. , Cambridge , Massachusetts 02139 , United States.
  • Seager BA; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Melbourne , VIC 3010 , Australia.
  • Charron CL; School of Chemistry, Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Melbourne , VIC 3010 , Australia.
  • Bruzzese F; Oncology Clinical R&D , Takeda Pharmaceuticals International Co. , Cambridge , Massachusetts 02139 , United States.
  • Yang X; Oncology Clinical R&D , Takeda Pharmaceuticals International Co. , Cambridge , Massachusetts 02139 , United States.
  • Zhao X; Oncology Clinical R&D , Takeda Pharmaceuticals International Co. , Cambridge , Massachusetts 02139 , United States.
  • Huang SC; Oncology Clinical R&D , Takeda Pharmaceuticals International Co. , Cambridge , Massachusetts 02139 , United States.
  • Hutton CA; School of Chemistry, Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Melbourne , VIC 3010 , Australia.
  • Burrows JN; Medicines for Malaria Venture , 1215 Meyrin , Switzerland.
  • Winzeler EA; Host-Microbe Systems and Therapeutics Division , UC San Diego School of Medicine , La Jolla , California 92093 , United States.
  • Avery VM; Griffith Institute for Drug Discovery , Griffith University , Brisbane , QLD 4111 , Australia.
  • Dick LR; Oncology Clinical R&D , Takeda Pharmaceuticals International Co. , Cambridge , Massachusetts 02139 , United States.
  • Tilley L; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Melbourne , VIC 3010 , Australia.
J Med Chem ; 61(22): 10053-10066, 2018 11 21.
Article em En | MEDLINE | ID: mdl-30373366
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Ácidos Borônicos / Desenho de Fármacos / Complexo de Endopeptidases do Proteassoma / Inibidores de Proteassoma Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Ácidos Borônicos / Desenho de Fármacos / Complexo de Endopeptidases do Proteassoma / Inibidores de Proteassoma Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália