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Elucidating the Beneficial Role of PPAR Agonists in Cardiac Diseases.
Khuchua, Zaza; Glukhov, Aleksandr I; Strauss, Arnold W; Javadov, Sabzali.
Afiliação
  • Khuchua Z; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229-7020,USA. zkhuchua@gmail.com.
  • Glukhov AI; Department of Biochemistry, Sechenov University, Moscow, 119991 Russia. zkhuchua@gmail.com.
  • Strauss AW; Department of Biochemistry, Ilia University, Tbilisi, 0162 Georgia. zkhuchua@gmail.com.
  • Javadov S; Department of Biochemistry, Sechenov University, Moscow, 119991 Russia. arnold.strauss@cchmc.org.
Int J Mol Sci ; 19(11)2018 Nov 04.
Article em En | MEDLINE | ID: mdl-30400386
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that bind to DNA and regulate transcription of genes involved in lipid and glucose metabolism. A growing number of studies provide strong evidence that PPARs are the promising pharmacological targets for therapeutic intervention in various diseases including cardiovascular disorders caused by compromised energy metabolism. PPAR agonists have been widely used for decades as lipid-lowering and anti-inflammatory drugs. Existing studies are mainly focused on the anti-atherosclerotic effects of PPAR agonists; however, their role in the maintenance of cellular bioenergetics remains unclear. Recent studies on animal models and patients suggest that PPAR agonists can normalize lipid metabolism by stimulating fatty acid oxidation. These studies indicate the importance of elucidation of PPAR agonists as potential pharmacological agents for protection of the heart from energy deprivation. Here, we summarize and provide a comprehensive analysis of previous studies on the role of PPARs in the heart under normal and pathological conditions. In addition, the review discusses the PPARs as a therapeutic target and the beneficial effects of PPAR agonists, particularly bezafibrate, to attenuate cardiomyopathy and heart failure in patients and animal models.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiotônicos / Receptores Ativados por Proliferador de Peroxissomo / Metabolismo Energético / Aterosclerose / Insuficiência Cardíaca / Cardiomiopatias Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiotônicos / Receptores Ativados por Proliferador de Peroxissomo / Metabolismo Energético / Aterosclerose / Insuficiência Cardíaca / Cardiomiopatias Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos