The FGF1/CPP-C chimera protein protects against intestinal adverse effects of C-ion radiotherapy without exacerbating pancreatic carcinoma.

Kawano, Mitsuko; Miura, Taichi; Fujita, Mayumi; Koike, Sachiko; Imadome, Kaori; Ishikawa, Atsuko; Yasuda, Takeshi; Imamura, Toru; Imai, Takashi; Nakayama, Fumiaki

Kawano, Mitsuko; Miura, Taichi; Fujita, Mayumi; Koike, Sachiko; Imadome, Kaori; Ishikawa, Atsuko; Yasuda, Takeshi; Imamura, Toru; Imai, Takashi; Nakayama, Fumiaki.

Afiliação

Kawano M; National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Miura T; National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Fujita M; National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Koike S; National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Imadome K; National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Ishikawa A; National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Yasuda T; National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Imamura T; National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Imai T; School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji, Japan.
Nakayama F; National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Clin Transl Radiat Oncol ; 14: 8-16, 2019 Jan.

Article em En | MEDLINE | ID: mdl-30406211

Palavras-chave

C-ion, carbon ion; CPP, cell-penetrating peptide; Carbon ion radiotherapy; Cellular internalization; FGF, fibroblast growth factor; FGF1; FGFR, fibroblast growth factor receptor; HIMAC, Heavy Ion Medical Accelerator in Chiba; Intestinal adverse effects; Pancreatic carcinoma; Radioprotector; SOBP, spread-out Bragg peak; TBI, total body irradiation; TUNEL, terminal deoxynucleotidyl transferasemediated deoxyuridine triphosphate nick end labeling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Transl Radiat Oncol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

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