The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design.

Besneux, Matthieu; Greenshields-Watson, Alexander; Scurr, Martin J; MacLachlan, Bruce J; Christian, Adam; Davies, Michael M; Hargest, Rachel; Phillips, Simon; Godkin, Andrew; Gallimore, Awen

Besneux, Matthieu; Greenshields-Watson, Alexander; Scurr, Martin J; MacLachlan, Bruce J; Christian, Adam; Davies, Michael M; Hargest, Rachel; Phillips, Simon; Godkin, Andrew; Gallimore, Awen.

Afiliação

Besneux M; Division of Infection and Immunity, Henry Wellcome Building, Cardiff University, Health Park, Cardiff, CF14 4XN, UK.
Greenshields-Watson A; Division of Infection and Immunity, Henry Wellcome Building, Cardiff University, Health Park, Cardiff, CF14 4XN, UK.
Scurr MJ; Division of Infection and Immunity, Henry Wellcome Building, Cardiff University, Health Park, Cardiff, CF14 4XN, UK.
MacLachlan BJ; Division of Infection and Immunity, Henry Wellcome Building, Cardiff University, Health Park, Cardiff, CF14 4XN, UK.
Christian A; Department of Pathology, University Hospital of Wales, Cardiff, UK.
Davies MM; Department of Colorectal Surgery, University Hospital of Wales, Cardiff, UK.
Hargest R; Department of Colorectal Surgery, University Hospital of Wales, Cardiff, UK.
Phillips S; CCMRC, Division of Cancer and Genetics, Henry Wellcome Building, Cardiff University, Cardiff, UK.
Godkin A; Department of Colorectal Surgery, University Hospital of Wales, Cardiff, UK.
Gallimore A; Division of Infection and Immunity, Henry Wellcome Building, Cardiff University, Health Park, Cardiff, CF14 4XN, UK. GodkinAJ@cardiff.ac.uk.

Cancer Immunol Immunother ; 68(2): 247-256, 2019 Feb.

Article em En | MEDLINE | ID: mdl-30406375

Assuntos

Antígenos de Neoplasias/imunologia; Vacinas Anticâncer/imunologia; Neoplasias Colorretais/imunologia; Linfócitos T Reguladores/imunologia; Linfócitos T/imunologia; Antígenos de Neoplasias/metabolismo; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD4-Positivos/metabolismo; Células Cultivadas; Neoplasias Colorretais/metabolismo; Desenho de Fármacos; Epitopos/imunologia; Epitopos/metabolismo; Antígenos HLA-DR/imunologia; Humanos; Interferon gama/imunologia; Interferon gama/metabolismo; Peptídeos/imunologia; Peptídeos/metabolismo; Linfócitos T/metabolismo; Linfócitos T Reguladores/metabolismo; Células Th1/imunologia; Células Th1/metabolismo

Palavras-chave

5T4; Antigen specificity; Cancer; Regulatory T cells; T cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Neoplasias Colorretais / Linfócitos T Reguladores / Vacinas Anticâncer / Antígenos de Neoplasias Limite: Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2019 Tipo de documento: Article

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