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Identification and regulation of the long non-coding RNA Heat2 in heart failure.
Boeckel, Jes-Niels; Perret, Maya F; Glaser, Simone F; Seeger, Timon; Heumüller, Andreas W; Chen, Wei; John, David; Kokot, Karoline E; Katus, Hugo A; Haas, Jan; Lackner, Maximilian K; Kayvanpour, Elham; Grabe, Niels; Dieterich, Christoph; von Haehling, Stephan; Ebner, Nicole; Hünecke, Sabine; Leuschner, Florian; Fichtlscherer, Stephan; Meder, Benjamin; Zeiher, Andreas M; Dimmeler, Stefanie; Keller, Till.
Afiliação
  • Boeckel JN; Institute for Cardiovascular Regeneration, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; Clinic and Polyclinic for Cardiology, University Hospital Leipzig, Ger
  • Perret MF; Institute for Cardiovascular Regeneration, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany.
  • Glaser SF; Institute for Cardiovascular Regeneration, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.
  • Seeger T; Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany.
  • Heumüller AW; Institute for Cardiovascular Regeneration, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.
  • Chen W; Laboratory for Novel sequencing technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum for Molecular Medicine, Berlin, Germany; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • John D; Institute for Cardiovascular Regeneration, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.
  • Kokot KE; Clinic and Polyclinic for Cardiology, University Hospital Leipzig, Germany.
  • Katus HA; Clinic and Polyclinic for Cardiology, University Hospital Leipzig, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany.
  • Haas J; Clinic and Polyclinic for Cardiology, University Hospital Leipzig, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany.
  • Lackner MK; Clinic and Polyclinic for Cardiology, University Hospital Leipzig, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany.
  • Kayvanpour E; Clinic and Polyclinic for Cardiology, University Hospital Leipzig, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany.
  • Grabe N; Medical Oncology, NCT Heidelberg, Heidelberg, Germany; Hamamatsu Tissue Imaging and Analysis Center, Bioquant, University Heidelberg, Heidelberg, Germany.
  • Dieterich C; Clinic and Polyclinic for Cardiology, University Hospital Leipzig, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany.
  • von Haehling S; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany; Heart center, Cardiology department, University Göttingen, Germany.
  • Ebner N; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany; Heart center, Cardiology department, University Göttingen, Germany.
  • Hünecke S; Division for Pediatric Stem-Cell Transplantation and Immunology, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany.
  • Leuschner F; Clinic and Polyclinic for Cardiology, University Hospital Leipzig, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany.
  • Fichtlscherer S; Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.
  • Meder B; Clinic and Polyclinic for Cardiology, University Hospital Leipzig, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany.
  • Zeiher AM; Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.
  • Dimmeler S; Institute for Cardiovascular Regeneration, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.
  • Keller T; Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany; Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany.
J Mol Cell Cardiol ; 126: 13-22, 2019 01.
Article em En | MEDLINE | ID: mdl-30445017
AIMS: Circulating immune cells have a significant impact on progression and outcome of heart failure. Long non-coding RNAs (lncRNAs) comprise novel epigenetic regulators which control cardiovascular diseases and inflammatory disorders. We aimed to identify lncRNAs regulated in circulating immune cells of the blood of heart failure patients. METHODS AND RESULTS: Next-generation sequencing revealed 110 potentially non-coding RNA transcripts differentially expressed in peripheral blood mononuclear cells of heart failure patients with reduced ejection fraction. The up-regulated lncRNA Heat2 was further functionally characterized. Heat2 expression was detected in whole blood, PBMNCs, eosinophil and basophil granulocytes. Heat2 regulates cell division, invasion, transmigration and immune cell adhesion on endothelial cells. CONCLUSION: Heat2 is an immune cell enriched lncRNA that is elevated in the blood of heart failure patients and controls cellular functions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / RNA Longo não Codificante / Insuficiência Cardíaca Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Mol Cell Cardiol Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / RNA Longo não Codificante / Insuficiência Cardíaca Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Mol Cell Cardiol Ano de publicação: 2019 Tipo de documento: Article