TIA1 regulates the generation and response to toxic tau oligomers.

Jiang, Lulu; Ash, Peter E A; Maziuk, Brandon F; Ballance, Heather I; Boudeau, Samantha; Abdullatif, Ali Al; Orlando, Marcello; Petrucelli, Leonard; Ikezu, Tsuneya; Wolozin, Benjamin

Jiang, Lulu; Ash, Peter E A; Maziuk, Brandon F; Ballance, Heather I; Boudeau, Samantha; Abdullatif, Ali Al; Orlando, Marcello; Petrucelli, Leonard; Ikezu, Tsuneya; Wolozin, Benjamin.

Afiliação

Jiang L; Department of Pharmacology and Experimental Therapeutics, Boston University, School of Medicine, Boston, MA, 02118, USA.
Ash PEA; Department of Pharmacology and Experimental Therapeutics, Boston University, School of Medicine, Boston, MA, 02118, USA.
Maziuk BF; Department of Pharmacology and Experimental Therapeutics, Boston University, School of Medicine, Boston, MA, 02118, USA.
Ballance HI; Department of Pharmacology and Experimental Therapeutics, Boston University, School of Medicine, Boston, MA, 02118, USA.
Boudeau S; Department of Pharmacology and Experimental Therapeutics, Boston University, School of Medicine, Boston, MA, 02118, USA.
Abdullatif AA; Department of Pharmacology and Experimental Therapeutics, Boston University, School of Medicine, Boston, MA, 02118, USA.
Orlando M; Department of Pharmacology and Experimental Therapeutics, Boston University, School of Medicine, Boston, MA, 02118, USA.
Petrucelli L; Neuroscience Division, Mayo Clinic, Jacksonville, FL, 32224, USA.
Ikezu T; Department of Pharmacology and Experimental Therapeutics, Boston University, School of Medicine, Boston, MA, 02118, USA.
Wolozin B; Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA.

Acta Neuropathol ; 137(2): 259-277, 2019 02.

Article em En | MEDLINE | ID: mdl-30465259

Assuntos

Encéfalo/patologia; Antígeno-1 Intracelular de Células T/metabolismo; Tauopatias/metabolismo; Proteínas tau/metabolismo; Animais; Modelos Animais de Doenças; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Neurônios/patologia; Tauopatias/patologia

Palavras-chave

Neurodegeneration; Neuropathology; RNA binding proteins; Stress granules; TIA1; Tau fibrils; Tau oligomers; Tau propagation; Tauopathy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Proteínas tau / Tauopatias / Antígeno-1 Intracelular de Células T Limite: Animals Idioma: En Revista: Acta Neuropathol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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