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Combination treatment of acute myeloid leukemia cells with DNMT and HDAC inhibitors: predominant synergistic gene downregulation associated with gene body demethylation.
Blagitko-Dorfs, Nadja; Schlosser, Pascal; Greve, Gabriele; Pfeifer, Dietmar; Meier, Ruth; Baude, Annika; Brocks, David; Plass, Christoph; Lübbert, Michael.
Afiliação
  • Blagitko-Dorfs N; Division of Hematology, Oncology and Stem Cell Transplantation, Department of Internal Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Schlosser P; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Freiburg, Germany.
  • Greve G; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Pfeifer D; Division of Hematology, Oncology and Stem Cell Transplantation, Department of Internal Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Meier R; Division of Hematology, Oncology and Stem Cell Transplantation, Department of Internal Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Baude A; Division of Hematology, Oncology and Stem Cell Transplantation, Department of Internal Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Brocks D; Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.
  • Plass C; Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.
  • Lübbert M; Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.
Leukemia ; 33(4): 945-956, 2019 04.
Article em En | MEDLINE | ID: mdl-30470836
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Regulação Neoplásica da Expressão Gênica / Metilação de DNA / Sinergismo Farmacológico / Inibidores Enzimáticos / Inibidores de Histona Desacetilases / Decitabina Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Regulação Neoplásica da Expressão Gênica / Metilação de DNA / Sinergismo Farmacológico / Inibidores Enzimáticos / Inibidores de Histona Desacetilases / Decitabina Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha