Clinical features and outcomes in young adults with oral tongue cancer.
Am J Otolaryngol
; 40(1): 93-96, 2019.
Article
em En
| MEDLINE
| ID: mdl-30472130
ABSTRACT
OBJECTIVE:
To evaluate outcomes and survival in young patients with oral tongue cancer (OTC).METHODS:
Retrospective chart review of patients aged 18-40 with OTC treated between 2000 and 2016. Tumor characteristics of p16 expression, perineural invasion (PNI), and lymph-vascular invasion (LVI) were evaluated. Recurrence-free (RFS) and overall survival (OS) data were analyzed according to Kaplan-Meier method with univariate analysis.RESULTS:
A total of 23 patients were identified 12 with early stage disease (ESD, stage I), and 11 with advanced stage disease (ASD, stage III or IV), (17 men and 6 women). Mean age at presentation was 34.5â¯years (±5â¯months) and mean follow-up was 46.6â¯months. For all patients, 5-year RFS was 62% and OS 66%. RFS for ESD was 73% and ASD 25% (log rank pâ¯=â¯0.011). OS for ESD was 100% and ASD 55% (log rank pâ¯=â¯0.012). 22% indicated tobacco use >5 pack-years and 9% heavy alcohol use. Factors associated with worse OS were neck disease (log rank pâ¯=â¯0.073), positive margins (log rank pâ¯=â¯0.001), and LVI (log rank pâ¯=â¯0.002). Factors associated with worse RFS were chemotherapy or radiation therapy prior to surgery (log rank pâ¯=â¯0.002), neck disease (log rank pâ¯=â¯0.047), positive margins (log rank pâ¯=â¯0.039), and PNI (log rank pâ¯=â¯0.001). Expression of p16 was observed in five cases and was not significantly associated with OS or RFS.CONCLUSION:
In young patients with OTC, factors associated with worse outcomes are similar to known predictors in older patients. Expression of p16 was not statistically associated with improved OS. OS in patients with ESD was excellent (100%), and significantly worse for ASD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Língua
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Otolaryngol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos