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Differential expression profiles and functional analysis of plasma miRNAs associated with chronic myeloid leukemia phases.
Zhang, Ji; Jiang, Yawen; Han, Xu; Roy, Mridul; Liu, Wenen; Zhao, Xielan; Liu, Jing.
Afiliação
  • Zhang J; Molecular Biology Research Center, School of Life Sciences, Central South University, Changsha 410078, PR China.
  • Jiang Y; Department of Clinical Laboratory, The First Affiliated Hospital, University of South China, Hengyang 421001, PR China.
  • Han X; Molecular Biology Research Center, School of Life Sciences, Central South University, Changsha 410078, PR China.
  • Roy M; Molecular Biology Research Center, School of Life Sciences, Central South University, Changsha 410078, PR China.
  • Liu W; Molecular Biology Research Center, School of Life Sciences, Central South University, Changsha 410078, PR China.
  • Zhao X; Department of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha 410008, PR China.
  • Liu J; Department of Hematology, Xiangya Hospital of Central South University, Changsha 410008, PR China.
Future Oncol ; 15(7): 763-776, 2019 Mar.
Article em En | MEDLINE | ID: mdl-30501399
ABSTRACT

AIM:

This study was aimed to investigate the expression profiles and biological function of plasma miRNAs at different phases of chronic myeloid leukemia (CML). MATERIALS &

METHODS:

Differentially expressed miRNAs were identified by microarray. The candidate miRNAs were validated by quantitative real-time PCR at chronic phase, accelerated phase and blast crisis. The functional analysis of miRNAs was carried out by using DAVID.

RESULTS:

The putative targets of dysregulated miRNAs were involved in important signaling pathways. Plasma let-7b-5p and miR-451a expression was lower in CML patients, and plasma miR-451a gradually decreased from chronic phase to accelerated phase and blast crisis.

CONCLUSION:

Dysregulated plasma miRNAs maybe play regulatory roles in pathogenesis of CML. Let-7b-5p and miR-451a can be used as potential biomarkers for the diagnosis and prognosis of CML.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mielogênica Crônica BCR-ABL Positiva / Biomarcadores Tumorais / Regulação Leucêmica da Expressão Gênica / MicroRNAs Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Future Oncol Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mielogênica Crônica BCR-ABL Positiva / Biomarcadores Tumorais / Regulação Leucêmica da Expressão Gênica / MicroRNAs Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Future Oncol Ano de publicação: 2019 Tipo de documento: Article