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Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
Danese, Elisa; Raimondi, Sara; Montagnana, Martina; Tagetti, Angela; Langaee, Taimour; Borgiani, Paola; Ciccacci, Cinzia; Carcas, Antonio J; Borobia, Alberto M; Tong, Hoi Y; Dávila-Fajardo, Cristina; Rodrigues Botton, Mariana; Bourgeois, Stephane; Deloukas, Panos; Caldwell, Michael D; Burmester, Jim K; Berg, Richard L; Cavallari, Larisa H; Drozda, Katarzyna; Huang, Min; Zhao, Li-Zi; Cen, Han-Jing; Gonzalez-Conejero, Rocio; Roldan, Vanessa; Nakamura, Yusuke; Mushiroda, Taisei; Gong, Inna Y; Kim, Richard B; Hirai, Keita; Itoh, Kunihiko; Isaza, Carlos; Beltrán, Leonardo; Jiménez-Varo, Enrique; Cañadas-Garre, Marisa; Giontella, Alice; Kringen, Marianne K; Haug, Kari Bente Foss; Gwak, Hye Sun; Lee, Kyung Eun; Minuz, Pietro; Lee, Ming Ta Michael; Lubitz, Steven A; Scott, Stuart; Mazzaccara, Cristina; Sacchetti, Lucia; Genç, Ece; Özer, Mahmut; Pathare, Anil; Krishnamoorthy, Rajagopal; Paldi, Andras.
Afiliação
  • Danese E; Clinical Biochemistry Section, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy.
  • Raimondi S; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.
  • Montagnana M; Clinical Biochemistry Section, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy.
  • Tagetti A; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.
  • Langaee T; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Borgiani P; Genetics Section, Department of Biomedicine and Prevention, University of Rome "Tor Vergata,", Rome, Italy.
  • Ciccacci C; Genetics Section, Department of Biomedicine and Prevention, University of Rome "Tor Vergata,", Rome, Italy.
  • Carcas AJ; Clinical Pharmacology Department, La Paz University Hospital, School of Medicine, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.
  • Borobia AM; Spanish Clinical Research Network-SCReN, Madrid, Spain.
  • Tong HY; Clinical Pharmacology Department, La Paz University Hospital, School of Medicine, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.
  • Dávila-Fajardo C; Spanish Clinical Research Network-SCReN, Madrid, Spain.
  • Rodrigues Botton M; Clinical Pharmacology Department, La Paz University Hospital, School of Medicine, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.
  • Bourgeois S; Spanish Clinical Research Network-SCReN, Madrid, Spain.
  • Deloukas P; Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, IBS, Granada, Spain.
  • Caldwell MD; Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Burmester JK; William Harvey Research Institute, Barts & the London Medical School, Queen Mary University of London, London, UK.
  • Berg RL; William Harvey Research Institute, Barts & the London Medical School, Queen Mary University of London, London, UK.
  • Cavallari LH; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
  • Drozda K; Center for Hyperbaric Medicine and Tissue Repair, Marshfield Clinic, Marshfield, Wisconsin, USA.
  • Huang M; Grants Office, Gundersen Health System, La Crosse, Wisconsin, USA.
  • Zhao LZ; Clinical Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA.
  • Cen HJ; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Gonzalez-Conejero R; Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois, USA.
  • Roldan V; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
  • Nakamura Y; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
  • Mushiroda T; Guangzhou Women and Children's Medical Center, Guangzhou, China.
  • Gong IY; Centro Regional de Hemodonación, Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain.
  • Kim RB; Centro Regional de Hemodonación, Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain.
  • Hirai K; Research Group for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Itoh K; Research Group for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Isaza C; Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.
  • Beltrán L; Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.
  • Jiménez-Varo E; Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
  • Cañadas-Garre M; Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
  • Giontella A; Faculty of Heath Sciences, Laboratory of Medical Genetics, Universidad Tecnológica de Pereira, Pereira, Colombia.
  • Kringen MK; Faculty of Heath Sciences, Laboratory of Medical Genetics, Universidad Tecnológica de Pereira, Pereira, Colombia.
  • Haug KBF; Faculty of Heath Sciences, Unidad Central del Valle del Cauca, Valle del Cauca, Colombia.
  • Gwak HS; Clinical Laboratory Department, Hospital La Línea, Cádiz, Spain.
  • Lee KE; Centre for Public Health, School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
  • Minuz P; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.
  • Lee MTM; Department of Pharmacology, Oslo University Hospital, Ullevål, Oslo, Norway.
  • Lubitz SA; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.
  • Scott S; Department of Medical Biochemistry, Oslo University Hospital, Ullevål, Oslo, Norway.
  • Mazzaccara C; Division of Life and Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea.
  • Sacchetti L; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.
  • Genç E; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.
  • Özer M; Genomic Medicine Institute, Geisinger Health System, Danville, Pennsylvania, USA.
  • Pathare A; National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Krishnamoorthy R; Cardiac Arrhythmia Service & Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Paldi A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Clin Pharmacol Ther ; 105(6): 1477-1491, 2019 06.
Article em En | MEDLINE | ID: mdl-30506689
ABSTRACT
The cytochrome P450 (CYP)4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at the individual patients level to capture the possible effect of ethnicity, gene-gene interaction, or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. The final collection consists of 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95% confidence interval (CI) 7-10%), with a higher effect in women, in patients taking acenocoumarol, and in white patients. The inclusion of the CYP4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cumarínicos / Polimorfismo de Nucleotídeo Único / Vitamina K Epóxido Redutases / Citocromo P-450 CYP2C9 / Família 4 do Citocromo P450 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Itália
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cumarínicos / Polimorfismo de Nucleotídeo Único / Vitamina K Epóxido Redutases / Citocromo P-450 CYP2C9 / Família 4 do Citocromo P450 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Itália