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Human monoclonal antibodies isolated from a primary pneumococcal conjugate Vaccinee demonstrates the expansion of an antigen-driven Hypermutated memory B cell response.
Chen, Zhifeng; Cox, Kara S; Tang, Aimin; Roman, Jeanette; Fink, Malorie; Kaufhold, Robin M; Guan, Liming; Xie, Andy; Boddicker, Melissa A; Mcguinness, Debra; Xiao, Xiao; Li, Hualin; Skinner, Julie M; Verch, Thorsten; Retzlaff, Mary; Vora, Kalpit A.
Afiliação
  • Chen Z; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Cox KS; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Tang A; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Roman J; Department of Vaccine Analytical Development - Immunoassay, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Fink M; Department of Vaccine Analytical Development - Immunoassay, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Kaufhold RM; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Guan L; Department of Vaccine Analytical Development - Immunoassay, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Xie A; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Boddicker MA; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Mcguinness D; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Xiao X; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Li H; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Skinner JM; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Verch T; Department of Vaccine Analytical Development - Immunoassay, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Retzlaff M; Department of Vaccine Analytical Development - Immunoassay, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Vora KA; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, Kenilworth, NJ, USA. kalpit.vora@merck.com.
BMC Infect Dis ; 18(1): 613, 2018 Dec 04.
Article em En | MEDLINE | ID: mdl-30509199
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Pneumocócicas / Linfócitos B / Vacinas Pneumocócicas / Hipermutação Somática de Imunoglobulina / Memória Imunológica / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Female / Humans Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Pneumocócicas / Linfócitos B / Vacinas Pneumocócicas / Hipermutação Somática de Imunoglobulina / Memória Imunológica / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Female / Humans Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos