Tumor-infiltrating lymphocytes: Streamlining a complex manufacturing process.
Cytotherapy
; 21(3): 307-314, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30509772
ABSTRACT
Adoptive cell therapy of tumor-infiltrating lymphocytes has shown promise for treatment of refractory melanoma and other solid malignancies; however, challenges to manufacturing have limited its widespread use. Traditional manufacturing efforts were lengthy, cumbersome and used open culture systems. We describe changes in testing and manufacturing that decreased the process cycle time, enhanced the robustness of critical quality attribute testing and facilitated a functionally closed system. These changes have enabled export of the manufacturing process to support multi-center clinical trials.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Controle de Qualidade
/
Imunoterapia Adotiva
/
Linfócitos do Interstício Tumoral
/
Técnicas de Cultura Celular por Lotes
Limite:
Humans
Idioma:
En
Revista:
Cytotherapy
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2019
Tipo de documento:
Article