Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator-activated receptor-alpha modulator, in rats and monkeys.

Ogawa, Shin-Ichiro; Tsunenari, Yoshihiko; Kawai, Hiroyuki; Yamazaki, Hiroshi

Ogawa, Shin-Ichiro; Tsunenari, Yoshihiko; Kawai, Hiroyuki; Yamazaki, Hiroshi.

Afiliação

Ogawa SI; Tokyo New Drug Research Laboratories, Kowa Co., Ltd, Higashimurayama, Tokyo, 189-0022, Japan.
Tsunenari Y; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Kawai H; Tokyo New Drug Research Laboratories, Kowa Co., Ltd, Higashimurayama, Tokyo, 189-0022, Japan.
Yamazaki H; Tokyo New Drug Research Laboratories, Kowa Co., Ltd, Higashimurayama, Tokyo, 189-0022, Japan.

Biopharm Drug Dispos ; 40(1): 12-17, 2019 Jan.

Article em En | MEDLINE | ID: mdl-30517973

Assuntos

Benzoxazóis/farmacocinética; Butiratos/farmacocinética; PPAR alfa/metabolismo; Animais; Feminino; Hepatócitos/metabolismo; Humanos; Macaca fascicularis; Masculino; Ratos Sprague-Dawley

Palavras-chave

cynomolgus macaque; hepatocytes; metabolic pathway; species difference

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzoxazóis / Butiratos / PPAR alfa Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Biopharm Drug Dispos Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

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