Salivary markers of hepato-metabolic comorbidities in pediatric obesity.
Dig Liver Dis
; 51(4): 516-523, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30528710
ABSTRACT
BACKGROUND:
The pediatric obesity epidemic calls for the noninvasive detection of individuals at higher risk of complications.AIMS:
To investigate the diagnostic role of combined salivary uric acid (UA), glucose and insulin levels to screen noninvasively for metabolic syndrome (MetS) and nonalcoholic fatty liver disease.METHODS:
Medical history, clinical, anthropometric, and laboratory data including serum triglyceride, glucose, insulin, HOMA, HDL-cholesterol, and UA levels of 23 obese children (15 with [St+] and 8 without [St-] ultrasonographic hepatic steatosis) and 18 normal weight controls were considered.RESULTS:
Serum and salivary UA (pâ¯<â¯0.05; R2â¯=â¯0.51), insulin (pâ¯<â¯0.0001; R2â¯=â¯0.79), and HOMA (pâ¯<â¯0.0001; R2â¯=â¯0.79) levels were significantly correlated; however their values tended to be only slightly higher in the obese patients, predominately in [St+], than in the controls. Notably, UA and insulin levels in both fluids increased in parallel to the number of MetS components. After conversion of the z-logit function including salivary/anthropometric parameters in a stepwise logistic regression analysis, a factor of 0.5 allowed for predicting hepatic steatosis with high sensitivity, specificity, and total accuracy.CONCLUSIONS:
Salivary testing together with selected anthropometric parameters helps to identify noninvasively obese children with hepatic steatosis and/or having MetS components.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saliva
/
Biomarcadores
/
Síndrome Metabólica
/
Obesidade Infantil
/
Hepatopatia Gordurosa não Alcoólica
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Dig Liver Dis
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article