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Toward a solution for cardiac failure in the newborn.
Platt, Jeffrey L; West, Lori J; Chinnock, Richard E; Cascalho, Marilia.
Afiliação
  • Platt JL; Department of Surgery and Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan.
  • West LJ; Department of Pediatrics, Department of Surgery, Department of Immunology, Alberta Transplant Institute, University of Alberta, Edmonton, Alberta, Canada.
  • Chinnock RE; Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California.
  • Cascalho M; Department of Surgery and Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan.
Xenotransplantation ; 25(6): e12479, 2018 11.
Article em En | MEDLINE | ID: mdl-30537350
The newborn infant with severe cardiac failure owed to congenital structural heart disease or cardiomyopathy poses a daunting therapeutic challenge. The ideal solution for both might be cardiac transplantation if availability of hearts was not limiting and if tolerance could be induced, obviating toxicity of immunosuppressive therapy. If one could safely and effectively exploit neonatal tolerance for successful xenotransplantation of the heart, the challenge of severe cardiac failure in the newborn infant might be met. We discuss the need, the potential for applying neonatal tolerance in the setting of xenotransplantation and the possibility that other approaches to this problem might emerge.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante Heterólogo / Transplante de Coração / Rejeição de Enxerto / Cardiopatias Congênitas / Insuficiência Cardíaca Limite: Animals / Humans / Newborn Idioma: En Revista: Xenotransplantation Assunto da revista: TRANSPLANTE Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante Heterólogo / Transplante de Coração / Rejeição de Enxerto / Cardiopatias Congênitas / Insuficiência Cardíaca Limite: Animals / Humans / Newborn Idioma: En Revista: Xenotransplantation Assunto da revista: TRANSPLANTE Ano de publicação: 2018 Tipo de documento: Article