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HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis.
Delbrel, Eva; Soumare, Abdoulaye; Naguez, Adnan; Label, Rabab; Bernard, Olivier; Bruhat, Alain; Fafournoux, Pierre; Tremblais, Geoffrey; Marchant, Dominique; Gille, Thomas; Bernaudin, Jean-François; Callard, Patrice; Kambouchner, Marianne; Martinod, Emmanuel; Valeyre, Dominique; Uzunhan, Yurdagül; Planès, Carole; Boncoeur, Emilie.
Afiliação
  • Delbrel E; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Soumare A; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Naguez A; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Label R; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Bernard O; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Bruhat A; Institut National de la Recherche Agronomique (INRA), UMR-1019 Nutrition Humaine, Centre INRA Auvergne Rhône-Alpes, Clermont Auvergne Université, 63122, Saint Genès Champanelle, France.
  • Fafournoux P; Institut National de la Recherche Agronomique (INRA), UMR-1019 Nutrition Humaine, Centre INRA Auvergne Rhône-Alpes, Clermont Auvergne Université, 63122, Saint Genès Champanelle, France.
  • Tremblais G; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Marchant D; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Gille T; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Bernaudin JF; APHP, Hôpital Avicenne, F-93017, Bobigny, France.
  • Callard P; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Kambouchner M; APHP, Hôpital Avicenne, F-93017, Bobigny, France.
  • Martinod E; Sorbonne Université, Faculté de Médecine, 75013, Paris, France.
  • Valeyre D; Sorbonne Université, Faculté de Médecine, 75013, Paris, France.
  • Uzunhan Y; APHP, Hôpital Avicenne, F-93017, Bobigny, France.
  • Planès C; Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.
  • Boncoeur E; APHP, Hôpital Avicenne, F-93017, Bobigny, France.
Sci Rep ; 8(1): 17939, 2018 12 18.
Article em En | MEDLINE | ID: mdl-30560874
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Subunidade alfa do Fator 1 Induzível por Hipóxia / Fator de Transcrição CHOP / Fibrose Pulmonar Idiopática / Células Epiteliais Alveolares / Estresse do Retículo Endoplasmático Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Subunidade alfa do Fator 1 Induzível por Hipóxia / Fator de Transcrição CHOP / Fibrose Pulmonar Idiopática / Células Epiteliais Alveolares / Estresse do Retículo Endoplasmático Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França