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Molecular detection of dengue virus in patients suspected of Ebola virus disease in Ghana.
Bonney, Joseph Humphrey Kofi; Hayashi, Takaya; Dadzie, Samuel; Agbosu, Esinam; Pratt, Deborah; Nyarko, Stephen; Asiedu-Bekoe, Franklin; Ido, Eiji; Sarkodie, Badu; Ohta, Nobuo; Yamaoka, Shoji.
Afiliação
  • Bonney JHK; Virology Department, Noguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
  • Hayashi T; Virology Department, Noguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
  • Dadzie S; Tokyo Medical and Dental University, Tokyo, Japan.
  • Agbosu E; Virology Department, Noguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
  • Pratt D; Virology Department, Noguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
  • Nyarko S; Virology Department, Noguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
  • Asiedu-Bekoe F; Virology Department, Noguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
  • Ido E; Disease Surveillance Department, Ghana Health Service, Accra, Ghana.
  • Sarkodie B; Tokyo Medical and Dental University, Tokyo, Japan.
  • Ohta N; Public Health Division, Ghana Health Service, Accra, Ghana.
  • Yamaoka S; Tokyo Medical and Dental University, Tokyo, Japan.
PLoS One ; 13(12): e0208907, 2018.
Article em En | MEDLINE | ID: mdl-30566466
Dengue fever is known to be one of the most common arthropod-borne viral infectious diseases of public health importance. The disease is now endemic in more than 100 countries in Africa, the Americas, the Eastern Mediterranean, Southeast Asia and the Western Pacific with an estimated two fifths of the world's population being at risk. The notable endemic viral hemorrhagic fevers (VHFs) found in West Africa, including yellow fever, Lassa fever, Rift Valley fever, dengue fever and until recently Ebola have been responsible for most outbreaks with fatal consequences. These VHFs usually produce unclear acute febrile illness, especially in the acute phase of infection. In this study we detected the presence of 2 different serotypes (DENV-2 and DENV-3) of Dengue virus in 4 sera of 150 patients clinically suspected of Ebola virus disease during the Ebola Virus Disease (EVD) outbreak in West Africa with the use of serological and molecular test assays. Sequence data was successfully generated for DENV-3 and phylogenetic analysis of the envelope gene showed that the DENV-3 sequences had close homology with DENV-3 sequences from Senegal and India. This study documents molecular evidence of an indigenous Dengue fever viral infection in Ghana and therefore necessitates the need to have an efficient surveillance system to rapidly detect and control the dissemination of the different serotypes in the population which has the potential to cause outbreaks of dengue hemorrhagic fevers.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença pelo Vírus Ebola / Dengue / Vírus da Dengue / Ebolavirus Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Gana

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença pelo Vírus Ebola / Dengue / Vírus da Dengue / Ebolavirus Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Gana