Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.

Waldt, Natalie; Seifert, Anke; Demiray, Yunus Emre; Devroe, Eric; Turk, Benjamin E; Reichardt, Peter; Mix, Charlie; Reinhold, Annegret; Freund, Christian; Müller, Andreas J; Schraven, Burkhart; Stork, Oliver; Kliche, Stefanie

Waldt, Natalie; Seifert, Anke; Demiray, Yunus Emre; Devroe, Eric; Turk, Benjamin E; Reichardt, Peter; Mix, Charlie; Reinhold, Annegret; Freund, Christian; Müller, Andreas J; Schraven, Burkhart; Stork, Oliver; Kliche, Stefanie.

Afiliação

Waldt N; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany.
Seifert A; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany.
Demiray YE; Institute of Biology, Department of Genetics and Molecular Neurobiology, Otto-von-Guericke University, Magdeburg, Germany.
Devroe E; MD Anderson Cancer Center, University of Texas, Houston, TX, United States.
Turk BE; Department of Pharmacology, Yale School of Medicine, New Haven, CT, United States.
Reichardt P; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany.
Mix C; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany.
Reinhold A; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany.
Freund C; Protein Biochemistry Group, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany.
Müller AJ; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany.
Schraven B; Intravital Microscopy of Infection and Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Stork O; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany.
Kliche S; Department of Immune Control Helmholtz Center for Infection Research, Braunschweig, Germany.

Front Immunol ; 9: 2852, 2018.

Article em En | MEDLINE | ID: mdl-30568657

Assuntos

Filaminas/metabolismo; Antígeno-1 Associado à Função Linfocitária/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas/metabolismo; Receptores de Antígenos de Linfócitos T/metabolismo; Linfócitos T/imunologia; Proteínas Adaptadoras de Transdução de Sinal; Animais; Antígenos CD18/imunologia; Antígenos CD18/metabolismo; Células Cultivadas; Proteínas do Citoesqueleto/imunologia; Proteínas do Citoesqueleto/metabolismo; Filaminas/genética; Filaminas/imunologia; Células HEK293; Voluntários Saudáveis; Humanos; Células Jurkat; Ativação Linfocitária; Antígeno-1 Associado à Função Linfocitária/imunologia; Proteínas de Membrana/imunologia; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Knockout; Mutação; Proteínas de Neoplasias/imunologia; Proteínas de Neoplasias/metabolismo; Fosforilação/imunologia; Cultura Primária de Células; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/imunologia; Proteínas/genética; Receptores de Antígenos de Linfócitos T/imunologia; Serina/metabolismo; Linfócitos T/metabolismo; Talina/imunologia; Talina/metabolismo

Palavras-chave

Filamin A; Kindlin-3; LFA-1; Ndr2; T cells; TCR; Talin; inside-out signaling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Linfócitos T / Proteínas / Antígeno-1 Associado à Função Linfocitária / Proteínas Serina-Treonina Quinases / Filaminas Idioma: En Revista: Front Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

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