Melatonin ameliorates ANIT­induced cholestasis by activating Nrf2 through a PI3K/Akt­dependent pathway in rats.

Li, Yunzhou; Yu, Han; Xu, Zongying; Shi, Shaohua; Wang, Dingnan; Shi, Xinghua; Wang, Yuchen; Zeng, Baihui; Deng, Huifang; Deng, Xiulan; Zhong, Xianggen

Melatonin ameliorates ANITinduced cholestasis by activating Nrf2 through a PI3K/Aktdependent pathway in rats.

Li, Yunzhou; Yu, Han; Xu, Zongying; Shi, Shaohua; Wang, Dingnan; Shi, Xinghua; Wang, Yuchen; Zeng, Baihui; Deng, Huifang; Deng, Xiulan; Zhong, Xianggen.

Afiliação

Li Y; Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Yu H; Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Xu Z; Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Shi S; Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Wang D; Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Shi X; Department of Pharmacology, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Wang Y; Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Zeng B; Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Deng H; Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Deng X; Department of Pharmacology, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.
Zhong X; Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Chaoyang, Beijing 100029, P.R. China.

Mol Med Rep ; 19(2): 1185-1193, 2019 02.

Article em En | MEDLINE | ID: mdl-30569102

Assuntos

1-Naftilisotiocianato/farmacologia; Colestase/induzido quimicamente; Colestase/tratamento farmacológico; Melatonina/farmacologia; Fator 2 Relacionado a NF-E2/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais/efeitos dos fármacos; Alanina Transaminase/metabolismo; Animais; Antioxidantes/farmacologia; Aspartato Aminotransferases/metabolismo; Ácidos e Sais Biliares/metabolismo; Bilirrubina/metabolismo; Colestase/metabolismo; Glutamato-Cisteína Ligase/metabolismo; Glutationa/metabolismo; Fígado/efeitos dos fármacos; Fígado/metabolismo; Masculino; Estresse Oxidativo/efeitos dos fármacos; RNA Mensageiro/metabolismo; Ratos; Ratos Sprague-Dawley

Palavras-chave

melatonin; cholestasis; nuclear factor-erythroid 2-related factor-2; phosphoinositide-3 kinase/Akt-dependent pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Colestase / Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt / Fator 2 Relacionado a NF-E2 / Melatonina / 1-Naftilisotiocianato Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Mol Med Rep Ano de publicação: 2019 Tipo de documento: Article

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