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Population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development.
Okada, Naohiro; Ando, Shuntaro; Sanada, Motoyuki; Hirata-Mogi, Sachiko; Iijima, Yudai; Sugiyama, Hiroshi; Shirakawa, Toru; Yamagishi, Mika; Kanehara, Akiko; Morita, Masaya; Yagi, Tomoko; Hayashi, Noriyuki; Koshiyama, Daisuke; Morita, Kentaro; Sawada, Kingo; Ikegame, Tempei; Sugimoto, Noriko; Toriyama, Rie; Masaoka, Mio; Fujikawa, Shinya; Kanata, Sho; Tada, Mariko; Kirihara, Kenji; Yahata, Noriaki; Araki, Tsuyoshi; Jinde, Seiichiro; Kano, Yukiko; Koike, Shinsuke; Endo, Kaori; Yamasaki, Syudo; Nishida, Atsushi; Hiraiwa-Hasegawa, Mariko; Bundo, Miki; Iwamoto, Kazuya; Tanaka, Saori C; Kasai, Kiyoto.
Afiliação
  • Okada N; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Ando S; International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, Japan.
  • Sanada M; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Hirata-Mogi S; Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Iijima Y; Center for Applied Psychological Science, Kwansei Gakuin University, Nishinomiya, Japan.
  • Sugiyama H; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Shirakawa T; Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Yamagishi M; Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
  • Kanehara A; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Morita M; Department of Integrated Educational Sciences, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
  • Yagi T; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Hayashi N; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Koshiyama D; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Morita K; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Sawada K; Department of Child Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Ikegame T; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Sugimoto N; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Toriyama R; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Masaoka M; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Fujikawa S; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kanata S; Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Tada M; Department of Child Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kirihara K; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Yahata N; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Araki T; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Jinde S; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kano Y; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
  • Koike S; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Endo K; International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, Japan.
  • Yamasaki S; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Nishida A; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Hiraiwa-Hasegawa M; Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
  • Bundo M; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Iwamoto K; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Tanaka SC; Department of Child Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kasai K; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Psychiatry Clin Neurosci ; 73(5): 231-242, 2019 May.
Article em En | MEDLINE | ID: mdl-30588712
ABSTRACT

AIM:

Adolescence is a crucial stage of psychological development and is critically vulnerable to the onset of psychopathology. Our understanding of how the maturation of endocrine, epigenetics, and brain circuit may underlie psychological development in adolescence, however, has not been integrated. Here, we introduce our research project, the population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC), a longitudinal study to explore the neurobiological substrates of development during adolescence.

METHODS:

Participants in the first wave of the pn-TTC (pn-TTC-1) study were recruited from those of the TTC study, a large-scale epidemiological survey in which 3171 parent-adolescent pairs were recruited from the general population. Participants underwent psychological, cognitive, sociological, and physical assessment. Moreover, adolescents and their parents underwent magnetic resonance imaging (MRI; structural MRI, resting-state functional MRI, and magnetic resonance spectroscopy), and adolescents provided saliva samples for hormone analysis and for DNA analysis including epigenetics. Furthermore, the second wave (pn-TTC-2) followed similar methods as in the first wave.

RESULTS:

A total of 301 parent-adolescent pairs participated in the pn-TTC-1 study. Moreover, 281 adolescents participated in the pn-TTC-2 study, 238 of whom were recruited from the pn-TTC-1 sample. The instruction for data request is available at http//value.umin.jp/data-resource.html.

CONCLUSION:

The pn-TTC project is a large-scale and population-neuroscience-based survey with a plan of longitudinal biennial follow up. Through this approach we seek to elucidate adolescent developmental mechanisms according to biopsychosocial models. This current biomarker research project, using minimally biased samples recruited from the general population, has the potential to expand the new research field of population neuroscience.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sintomas Comportamentais / Encéfalo / Imageamento por Ressonância Magnética / Comportamento do Adolescente / Desenvolvimento do Adolescente / Epigênese Genética / Eletroencefalografia / Testes Neuropsicológicos Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Psychiatry Clin Neurosci Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sintomas Comportamentais / Encéfalo / Imageamento por Ressonância Magnética / Comportamento do Adolescente / Desenvolvimento do Adolescente / Epigênese Genética / Eletroencefalografia / Testes Neuropsicológicos Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Psychiatry Clin Neurosci Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão