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Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells.
Fernandez Esmerats, Joan; Villa-Roel, Nicolas; Kumar, Sandeep; Gu, Lina; Salim, Md Tausif; Ohh, Michael; Taylor, W Robert; Nerem, Robert M; Yoganathan, Ajit P; Jo, Hanjoong.
Afiliação
  • Fernandez Esmerats J; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta (J.F.E., N.V.-R., S.K., L.G., W.R.T., A.P.Y., H.J.).
  • Villa-Roel N; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta (J.F.E., N.V.-R., S.K., L.G., W.R.T., A.P.Y., H.J.).
  • Kumar S; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta (J.F.E., N.V.-R., S.K., L.G., W.R.T., A.P.Y., H.J.).
  • Gu L; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta (J.F.E., N.V.-R., S.K., L.G., W.R.T., A.P.Y., H.J.).
  • Salim MT; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta (M.T.S., A.P.Y.).
  • Ohh M; Department of Biochemistry, Faculty of Medicine, University of Toronto, Ontario, Canada (M.O.).
  • Taylor WR; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta (J.F.E., N.V.-R., S.K., L.G., W.R.T., A.P.Y., H.J.).
  • Nerem RM; Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA (W.R.T., H.J.).
  • Yoganathan AP; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta (R.M.N.).
  • Jo H; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta (J.F.E., N.V.-R., S.K., L.G., W.R.T., A.P.Y., H.J.).
Arterioscler Thromb Vasc Biol ; 39(3): 467-481, 2019 03.
Article em En | MEDLINE | ID: mdl-30602302
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valva Aórtica / Estenose da Valva Aórtica / Calcinose / Hemorreologia / MicroRNAs / Células Endoteliais / Enzimas de Conjugação de Ubiquitina / Proteína Supressora de Tumor Von Hippel-Lindau / Subunidade alfa do Fator 1 Induzível por Hipóxia Limite: Animals / Female / Humans Idioma: En Revista: Arterioscler Thromb Vasc Biol Assunto da revista: ANGIOLOGIA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valva Aórtica / Estenose da Valva Aórtica / Calcinose / Hemorreologia / MicroRNAs / Células Endoteliais / Enzimas de Conjugação de Ubiquitina / Proteína Supressora de Tumor Von Hippel-Lindau / Subunidade alfa do Fator 1 Induzível por Hipóxia Limite: Animals / Female / Humans Idioma: En Revista: Arterioscler Thromb Vasc Biol Assunto da revista: ANGIOLOGIA Ano de publicação: 2019 Tipo de documento: Article