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Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.
Wagner, Annika; Le, Thien Anh; Brennich, Martha; Klein, Philipp; Bader, Nicole; Diehl, Erika; Paszek, Daniel; Weickhmann, A Katharina; Dirdjaja, Natalie; Krauth-Siegel, R Luise; Engels, Bernd; Opatz, Till; Schindelin, Hermann; Hellmich, Ute A.
Afiliação
  • Wagner A; Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Johann-Joachim-Becherweg 31, 55128, Mainz, Germany.
  • Le TA; Biomolekulares Magnetresonanz Zentrum (BMRZ), Goethe-Universität Frankfurt, Max-von-Laue Str. 9, 60438, Frankfurt/M, Germany.
  • Brennich M; Institute of Physical and Theoretical Chemistry, Julius-Maximilians-University Würzburg, Emil-Fischer-Straße 42, 97074, Würzburg, Germany.
  • Klein P; Synchrotron Crystallography Team, EMBL Grenoble Outstation, 71 Avenue des Martyrs, 38042, Grenoble, France.
  • Bader N; Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.
  • Diehl E; Rudolf Virchow Center for Experimental Biomedicine, Julius-Maximilians-University Würzburg, Josef-Schneider-Straße 2, Haus D15, 97080, Würzburg, Germany.
  • Paszek D; Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Johann-Joachim-Becherweg 31, 55128, Mainz, Germany.
  • Weickhmann AK; Biomolekulares Magnetresonanz Zentrum (BMRZ), Goethe-Universität Frankfurt, Max-von-Laue Str. 9, 60438, Frankfurt/M, Germany.
  • Dirdjaja N; Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Johann-Joachim-Becherweg 31, 55128, Mainz, Germany.
  • Krauth-Siegel RL; Biomolekulares Magnetresonanz Zentrum (BMRZ), Goethe-Universität Frankfurt, Max-von-Laue Str. 9, 60438, Frankfurt/M, Germany.
  • Engels B; Biochemistry Center (BZH), Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 328, 69120, Heidelberg, Germany.
  • Opatz T; Biochemistry Center (BZH), Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 328, 69120, Heidelberg, Germany.
  • Schindelin H; Institute of Physical and Theoretical Chemistry, Julius-Maximilians-University Würzburg, Emil-Fischer-Straße 42, 97074, Würzburg, Germany.
  • Hellmich UA; Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.
Angew Chem Int Ed Engl ; 58(11): 3640-3644, 2019 03 11.
Article em En | MEDLINE | ID: mdl-30605929
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Tiorredoxinas / Proteínas de Bactérias / Trypanosoma brucei brucei / Inibidores Enzimáticos / Antiprotozoários Limite: Animals / Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Tiorredoxinas / Proteínas de Bactérias / Trypanosoma brucei brucei / Inibidores Enzimáticos / Antiprotozoários Limite: Animals / Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha