Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons.

Cioni, Jean-Michel; Lin, Julie Qiaojin; Holtermann, Anne V; Koppers, Max; Jakobs, Maximilian A H; Azizi, Afnan; Turner-Bridger, Benita; Shigeoka, Toshiaki; Franze, Kristian; Harris, William A; Holt, Christine E

Cioni, Jean-Michel; Lin, Julie Qiaojin; Holtermann, Anne V; Koppers, Max; Jakobs, Maximilian A H; Azizi, Afnan; Turner-Bridger, Benita; Shigeoka, Toshiaki; Franze, Kristian; Harris, William A; Holt, Christine E.

Afiliação

Cioni JM; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Lin JQ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Holtermann AV; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Koppers M; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Jakobs MAH; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Azizi A; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Turner-Bridger B; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Shigeoka T; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Franze K; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Harris WA; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Holt CE; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK. Electronic address: ceh33@cam.ac.uk.

Cell ; 176(1-2): 56-72.e15, 2019 01 10.

Article em En | MEDLINE | ID: mdl-30612743

Assuntos

Endossomos/fisiologia; Biossíntese de Proteínas/fisiologia; Proteínas rab de Ligação ao GTP/metabolismo; Animais; Axônios/metabolismo; Endossomos/metabolismo; Mitocôndrias/genética; Mitocôndrias/metabolismo; RNA/metabolismo; RNA Mensageiro/metabolismo; RNA Mensageiro/fisiologia; Células Ganglionares da Retina/metabolismo; Células Ganglionares da Retina/fisiologia; Ribossomos/metabolismo; Proteínas de Xenopus/metabolismo; Xenopus laevis/metabolismo; Proteínas rab de Ligação ao GTP/genética; Proteínas rab de Ligação ao GTP/fisiologia; proteínas de unión al GTP Rab7

Palavras-chave

Charcot-Marie-Tooth type 2B; RNA trafficking; axon maintenance; endosome; local protein synthesis; lysosome; mRNA translation; mitochondria; retinal ganglion cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endossomos / Biossíntese de Proteínas / Proteínas rab de Ligação ao GTP Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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