Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101.
Contact Dermatitis
; 80(5): 298-303, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30624788
ABSTRACT
BACKGROUND:
The prevalence of lanolin contact allergy in dermatitis patients varies from 1.2% to 6.9%. Different lanolin derivatives are used in patch testing.OBJECTIVES:
To determine which combination of lanolin derivatives is most effective in patch testing for the diagnosis of lanolin contact allergy.METHODS:
A retrospective analysis of patients patch tested between 2016 and 2017 was performed. Patients were eligible if they had been tested with lanolin alcohol 30% pet., Amerchol L101 50% pet., and a supplementary series containing other lanolin derivatives. Lanolin alcohol and Amerchol L101 were tested in duplicate.RESULTS:
Of 594 patients, 28.6% (95% confidence interval [CI] 25.1%-32.3%) had a positive patch test reaction to at least one lanolin derivative. Reactions to lanolin alcohol (14.7%, 95%CI 11.3%-18.2%) and Amerchol L101 (15.0%, 95%CI 11.5%-18.5%) were common in the routinely tested series. Reactions to other test preparations were significantly less frequent (P < 0.05). The addition of Amerchol L101 to lanolin alcohol significantly increased the number of positive cases (odds ratio 1.79, P < 0.001).CONCLUSIONS:
The combination of lanolin alcohol and Amerchol L101 is effective in patch testing for the diagnosis of lanolin contact allergy. Routinely testing with other lanolin derivatives may not be worthwhile, as it detects only a few additional patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes do Emplastro
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Dermatite Alérgica de Contato
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Lanolina
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Contact Dermatitis
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Holanda