Is Targeting the Folate Receptor in Ovarian Cancer Coming of Age?

Birrer, Michael J; Betella, Ilaria; Martin, Lainie P; Moore, Kathleen N

Birrer, Michael J; Betella, Ilaria; Martin, Lainie P; Moore, Kathleen N.

Afiliação

Birrer MJ; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA mbirrer@uab.edu.
Betella I; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Martin LP; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Moore KN; Stephenson Oklahoma Cancer Center at the University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Oncologist ; 24(4): 425-429, 2019 04.

Article em En | MEDLINE | ID: mdl-30635448

ABSTRACT

ABSTRACT

Prognosis for women with epithelial ovarian cancer remains poor. One new molecular target in epithelial ovarian cancer is folate receptor alpha (FRα). This commentary discusses the characteristics that contribute to its attractiveness as a candidate for therapeutic intervention.

Assuntos

Antineoplásicos/uso terapêutico; Carcinoma Epitelial do Ovário/tratamento farmacológico; Receptor 1 de Folato/antagonistas & inibidores; Carcinoma Epitelial do Ovário/metabolismo; Carcinoma Epitelial do Ovário/patologia; Ensaios Clínicos como Assunto; Feminino; Humanos; Terapia de Alvo Molecular; Prognóstico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor 1 de Folato / Carcinoma Epitelial do Ovário / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Oncologist Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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