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Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM.
Matheson, Elizabeth C; Thomas, Huw; Case, Marian; Blair, Helen; Jackson, Rosanna K; Masic, Dino; Veal, Gareth; Halsey, Chris; Newell, David R; Vormoor, Josef; Irving, Julie A E.
Afiliação
  • Matheson EC; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Thomas H; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Case M; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Blair H; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Jackson RK; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Masic D; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Veal G; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Halsey C; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow.
  • Newell DR; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Vormoor J; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Irving JAE; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Haematologica ; 104(9): 1804-1811, 2019 09.
Article em En | MEDLINE | ID: mdl-30655370
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Proteínas ras / Leucemia-Linfoma Linfoblástico de Células Precursoras / Proteína 11 Semelhante a Bcl-2 / Glucocorticoides Limite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Haematologica Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Proteínas ras / Leucemia-Linfoma Linfoblástico de Células Precursoras / Proteína 11 Semelhante a Bcl-2 / Glucocorticoides Limite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Haematologica Ano de publicação: 2019 Tipo de documento: Article