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A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors.
Menon, Malini; Elliott, Richard; Bowers, Leandra; Balan, Nicolae; Rafiq, Rumana; Costa-Cabral, Sara; Munkonge, Felix; Trinidade, Ines; Porter, Roderick; Campbell, Andrew D; Johnson, Emma R; Esdar, Christina; Buchstaller, Hans-Peter; Leuthner, Birgitta; Rohdich, Felix; Schneider, Richard; Sansom, Owen; Wienke, Dirk; Ashworth, Alan; Lord, Christopher J.
Afiliação
  • Menon M; CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
  • Elliott R; CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
  • Bowers L; CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
  • Balan N; CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
  • Rafiq R; CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
  • Costa-Cabral S; CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
  • Munkonge F; CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
  • Trinidade I; CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
  • Porter R; The Wellcome Trust, Euston Road, London, NW1 2BE, UK.
  • Campbell AD; CRUK Beatson Institute, Switchback Rd, Bearsden, Glasgow, G61 1BD, UK.
  • Johnson ER; CRUK Beatson Institute, Switchback Rd, Bearsden, Glasgow, G61 1BD, UK.
  • Esdar C; Merck KGaA, Biopharma Research & Development, Frankfurter Str. 250, 64293, Darmstadt, Germany.
  • Buchstaller HP; Merck KGaA, Biopharma Research & Development, Frankfurter Str. 250, 64293, Darmstadt, Germany.
  • Leuthner B; Merck KGaA, Biopharma Research & Development, Frankfurter Str. 250, 64293, Darmstadt, Germany.
  • Rohdich F; Merck KGaA, Biopharma Research & Development, Frankfurter Str. 250, 64293, Darmstadt, Germany.
  • Schneider R; Merck KGaA, Biopharma Research & Development, Frankfurter Str. 250, 64293, Darmstadt, Germany.
  • Sansom O; CRUK Beatson Institute, Switchback Rd, Bearsden, Glasgow, G61 1BD, UK.
  • Wienke D; Merck KGaA, Biopharma Research & Development, Frankfurter Str. 250, 64293, Darmstadt, Germany. Dirk.Wienke@merckgroup.com.
  • Ashworth A; CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK. Alan.Ashworth@ucsf.edu.
  • Lord CJ; UCSF Helen Diller Family Comprehensive Cancer Centre, San Francisco, 94158, USA. Alan.Ashworth@ucsf.edu.
Sci Rep ; 9(1): 201, 2019 01 17.
Article em En | MEDLINE | ID: mdl-30655555
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Neoplasias Colorretais / Tanquirases / Inibidores de Proteínas Quinases / Inibidores Enzimáticos Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Neoplasias Colorretais / Tanquirases / Inibidores de Proteínas Quinases / Inibidores Enzimáticos Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido