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Abnormal Cortico-Cerebellar Functional Connectivity in Autism Spectrum Disorder.
Ramos, Taiane Coelho; Balardin, Joana Bisol; Sato, João Ricardo; Fujita, André.
Afiliação
  • Ramos TC; Department of Computer Science, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil.
  • Balardin JB; Brain Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Sato JR; Center of Mathematics, Computation, and Cognition, Universidade Federal do ABC, Santo André, Brazil.
  • Fujita A; Department of Computer Science, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil.
Front Syst Neurosci ; 12: 74, 2018.
Article em En | MEDLINE | ID: mdl-30697151
The cerebral cortex and the cerebellum are spatially remote areas that are connected by complex circuits that link both primary and associative areas. Previous studies have revealed abnormalities in autism spectrum disorder (ASD); however, it is not clear whether cortico-cerebellar connectivity is differentially manifested in the disorder. To explore this issue, we investigated differences in intrinsic cortico-cerebellar functional connectivity between individuals with typical development (TD) and those with ASD. To this end, we used functional magnetic resonance imaging (fMRI) of 708 subjects under a resting state protocol provided by the ABIDE I Consortium. We found that people with ASD had diminished functional connectivity between the cerebellum and the following cortical regions: (i) right fusiform gyrus, (ii) right postcentral gyrus, (iii) right superior temporal gyrus, (iv) right middle temporal gyrus, and (v) left middle temporal gyrus. All of these regions are involved in many cognitive systems that contribute to commonly affected functions in ASD. For right fusiform gyrus, right superior temporal gyrus, and left middle temporal gyrus, we reproduced the results in an independent cohort composed of 585 subjects of the ABIDE II Consortium. Our results points toward a consistent atypical cortico-cerebellar connectivity in ASD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Syst Neurosci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Syst Neurosci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil