Your browser doesn't support javascript.
loading
Nickel-Catalyzed Kumada Coupling of Boc-Activated Aromatic Amines via Nondirected Selective Aryl C-N Bond Cleavage.
Zhang, Zheng-Bing; Ji, Chong-Lei; Yang, Ce; Chen, Jie; Hong, Xin; Xia, Ji-Bao.
Afiliação
  • Zhang ZB; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP) , University of Chinese Academy of Sciences, Chinese Academy of Sciences , Lanzhou 730000 , China.
  • Ji CL; Department of Chemistry , Zhejiang University , Hangzhou 310027 , China.
  • Yang C; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP) , University of Chinese Academy of Sciences, Chinese Academy of Sciences , Lanzhou 730000 , China.
  • Chen J; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP) , University of Chinese Academy of Sciences, Chinese Academy of Sciences , Lanzhou 730000 , China.
  • Hong X; Department of Chemistry , Zhejiang University , Hangzhou 310027 , China.
  • Xia JB; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP) , University of Chinese Academy of Sciences, Chinese Academy of Sciences , Lanzhou 730000 , China.
Org Lett ; 21(4): 1226-1231, 2019 02 15.
Article em En | MEDLINE | ID: mdl-30702298
A nickel-catalyzed Kumada coupling of aniline derivatives was developed by selective cleavage of aryl C-N bonds under mild reaction conditions. Without preinstallation of an ortho directing group on anilines, the cross-coupling reactions of Boc-protected aromatic amines with aryl Grignard reagents afforded unsymmetric biaryls. Mechanistic studies by DFT calculations revealed that the nickel-mediated C-N bond cleavage is the rate-limiting step.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China