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Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury.
Davies, Alexander J; Kim, Hyoung Woo; Gonzalez-Cano, Rafael; Choi, Jahyang; Back, Seung Keun; Roh, Seung Eon; Johnson, Errin; Gabriac, Melanie; Kim, Mi-Sun; Lee, Jaehee; Lee, Jeong Eun; Kim, Yun Sook; Bae, Yong Chul; Kim, Sang Jeong; Lee, Kyung-Mi; Na, Heung Sik; Riva, Priscilla; Latremoliere, Alban; Rinaldi, Simon; Ugolini, Sophie; Costigan, Michael; Oh, Seog Bae.
Afiliação
  • Davies AJ; Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
  • Kim HW; Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.
  • Gonzalez-Cano R; Departments of Anesthesia and Neurobiology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.
  • Choi J; Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea.
  • Back SK; Departments of Physiology, Biochemistry and Molecular Biology, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Roh SE; Department of Physiology, Seoul National University College of Medicine, Seoul 03087, Republic of Korea.
  • Johnson E; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
  • Gabriac M; Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
  • Kim MS; Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea.
  • Lee J; Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea; Departments of Physiology, Biochemistry and Molecular Biology, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Lee JE; Departments of Physiology, Biochemistry and Molecular Biology, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Kim YS; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 700-412, Korea.
  • Bae YC; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 700-412, Korea.
  • Kim SJ; Department of Physiology, Seoul National University College of Medicine, Seoul 03087, Republic of Korea.
  • Lee KM; Departments of Physiology, Biochemistry and Molecular Biology, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Na HS; Departments of Physiology, Biochemistry and Molecular Biology, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Riva P; Departments of Anesthesia and Neurobiology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.
  • Latremoliere A; Neurosurgery Department, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
  • Rinaldi S; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
  • Ugolini S; Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
  • Costigan M; Departments of Anesthesia and Neurobiology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA. Electronic address: michael.costigan@childrens.harvard.edu.
  • Oh SB; Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea; Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic addr
Cell ; 176(4): 716-728.e18, 2019 02 07.
Article em En | MEDLINE | ID: mdl-30712871
ABSTRACT
Sensory axons degenerate following separation from their cell body, but partial injury to peripheral nerves may leave the integrity of damaged axons preserved. We show that an endogenous ligand for the natural killer (NK) cell receptor NKG2D, Retinoic Acid Early 1 (RAE1), is re-expressed in adult dorsal root ganglion neurons following peripheral nerve injury, triggering selective degeneration of injured axons. Infiltration of cytotoxic NK cells into the sciatic nerve by extravasation occurs within 3 days following crush injury. Using a combination of genetic cell ablation and cytokine-antibody complex stimulation, we show that NK cell function correlates with loss of sensation due to degeneration of injured afferents and reduced incidence of post-injury hypersensitivity. This neuro-immune mechanism of selective NK cell-mediated degeneration of damaged but intact sensory axons complements Wallerian degeneration and suggests the therapeutic potential of modulating NK cell function to resolve painful neuropathy through the clearance of partially damaged nerves.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Proteínas de Transporte Nucleocitoplasmático / Proteínas Associadas à Matriz Nuclear / Traumatismos dos Nervos Periféricos Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Proteínas de Transporte Nucleocitoplasmático / Proteínas Associadas à Matriz Nuclear / Traumatismos dos Nervos Periféricos Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido