Inflammasome Inhibition Links IRGM to Innate Immunity.

Nabar, Neel R; Kehrl, John H

Nabar, Neel R; Kehrl, John H.

Afiliação

Nabar NR; B Cell Molecular Immunology Section, Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: neel.nabar@nih.gov.
Kehrl JH; B Cell Molecular Immunology Section, Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jkehrl@niaid.nih.gov.

Mol Cell ; 73(3): 391-392, 2019 02 07.

Article em En | MEDLINE | ID: mdl-30735651

ABSTRACT

ABSTRACT

IRGM is a risk factor for several inflammatory diseases, yet no direct link to immune regulation had been shown. In this issue of Molecular Cell, Mehto et al. (2019) report that IRGM limits NLRP3 inflammasome activation-by both direct inhibition of NLRP3/ASC oligomerization and selective autophagic destruction of NLRP3/ASC.

Assuntos

Autofagia; Doença de Crohn; Proteínas de Ligação ao GTP; Humanos; Imunidade Inata; Inflamassomos; Proteína 3 que Contém Domínio de Pirina da Família NLR; Fatores de Risco

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Doença de Crohn Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article

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