Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial Phyla.

Uribe, Ruben V; van der Helm, Eric; Misiakou, Maria-Anna; Lee, Sang-Woo; Kol, Stefan; Sommer, Morten O A

Uribe, Ruben V; van der Helm, Eric; Misiakou, Maria-Anna; Lee, Sang-Woo; Kol, Stefan; Sommer, Morten O A.

Afiliação

Uribe RV; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby 2800, Denmark.
van der Helm E; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby 2800, Denmark.
Misiakou MA; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby 2800, Denmark.
Lee SW; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby 2800, Denmark.
Kol S; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby 2800, Denmark.
Sommer MOA; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby 2800, Denmark. Electronic address: msom@bio.dtu.dk.

Cell Host Microbe ; 25(2): 233-241.e5, 2019 02 13.

Article em En | MEDLINE | ID: mdl-30737174

Assuntos

Proteína 9 Associada à CRISPR/antagonistas & inibidores; Inibidores Enzimáticos/isolamento & purificação; Metagenômica/métodos; Biblioteca Gênica; Testes Genéticos

Palavras-chave

CRISPR; Cas9 inhibitor; anti-CRISPR; functional metagenomics; genetic circuit

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Metagenômica / Proteína 9 Associada à CRISPR Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Dinamarca

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