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Ventilatory response to CO2 in patients with epilepsy.
Sainju, Rup K; Dragon, Deidre N; Winnike, Harold B; Nashelsky, Marcus B; Granner, Mark A; Gehlbach, Brian K; Richerson, George B.
Afiliação
  • Sainju RK; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
  • Dragon DN; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
  • Winnike HB; Institute for Clinical and Translational Science, University of Iowa Carver College of Medicine, Iowa City, Iowa.
  • Nashelsky MB; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
  • Granner MA; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
  • Gehlbach BK; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
  • Richerson GB; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Epilepsia ; 60(3): 508-517, 2019 03.
Article em En | MEDLINE | ID: mdl-30756391
OBJECTIVE: Severe periictal respiratory depression is thought to be linked to risk of sudden unexpected death in epilepsy (SUDEP) but its determinants are largely unknown. Interindividual differences in the interictal ventilatory response to CO2 (hypercapnic ventilatory response [HCVR] or central respiratory CO2 chemosensitivity) may identify patients who are at increased risk for severe periictal hypoventilation. HCVR has not been studied previously in patients with epilepsy; therefore we evaluated a method to measure it at bedside in an epilepsy monitoring unit (EMU) and examined its relationship to postictal hypercapnia following generalized convulsive seizures (GCSs). METHODS: Interictal HCVR was measured by a respiratory gas analyzer using a modified rebreathing technique. Minute ventilation (VE ), tidal volume, respiratory rate, end tidal (ET) CO2 and O2 were recorded continuously. Dyspnea during the test was assessed using a validated scale. The HCVR slope (ΔVE /ΔETCO2 ) for each subject was determined by linear regression. During the video-electroencephalography (EEG) study, subjects underwent continuous respiratory monitoring, including measurement of chest and abdominal movement, oronasal airflow, transcutaneous (tc) CO2 , and capillary oxygen saturation (SPO2 ). RESULTS: Sixty-eight subjects completed HCVR testing in 151 ± (standard deviation) 58 seconds, without any serious adverse events. HCVR slope ranged from -0.94 to 5.39 (median 1.71) L/min/mm Hg. HCVR slope correlated with the degree of unpleasantness and intensity of dyspnea and was inversely related to baseline ETCO2 . Both the duration and magnitude of postictal tcCO2 rise following GCSs were inversely correlated with HCVR slope. SIGNIFICANCE: Measurement of the HCVR is well tolerated and can be performed rapidly and safely at the bedside in the EMU. A subset of individuals has a very low sensitivity to CO2 , and this group is more likely to have a prolonged increase in postictal CO2 after GCS. Low interictal HCVR may increase the risk of severe respiratory depression and SUDEP after GCS and warrants further study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Respiração / Dióxido de Carbono / Epilepsia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Epilepsia Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Respiração / Dióxido de Carbono / Epilepsia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Epilepsia Ano de publicação: 2019 Tipo de documento: Article