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Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography.
Russo, Giacomo; Barbato, Francesco; Grumetto, Lucia; Philippe, Laurence; Lynen, Frederic; Goetz, Gilles H.
Afiliação
  • Russo G; Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, B-
  • Barbato F; Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy.
  • Grumetto L; Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy.
  • Philippe L; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, United States.
  • Lynen F; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, B-9000 Ghent, Belgium.
  • Goetz GH; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, United States. Electronic address: gilles.h.goetz@pfizer.com.
Int J Pharm ; 560: 294-305, 2019 Apr 05.
Article em En | MEDLINE | ID: mdl-30771469
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Barreira Hematoencefálica / Modelos Estatísticos / Cromatografia com Fluido Supercrítico Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Pharm Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Barreira Hematoencefálica / Modelos Estatísticos / Cromatografia com Fluido Supercrítico Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Pharm Ano de publicação: 2019 Tipo de documento: Article