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Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Francis, Stuart; Croft, Daniel; Schüttelkopf, Alexander W; Parry, Charles; Pugliese, Angelo; Cameron, Ken; Claydon, Sophie; Drysdale, Martin; Gardner, Claire; Gohlke, Andrea; Goodwin, Gillian; Gray, Christopher H; Konczal, Jennifer; McDonald, Laura; Mezna, Mokdad; Pannifer, Andrew; Paul, Nikki R; Machesky, Laura; McKinnon, Heather; Bower, Justin.
Afiliação
  • Francis S; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK. Electronic address: s.francis@beatson.gla.ac.uk.
  • Croft D; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Schüttelkopf AW; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Parry C; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Pugliese A; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Cameron K; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Claydon S; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Drysdale M; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Gardner C; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Gohlke A; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Goodwin G; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Gray CH; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Konczal J; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • McDonald L; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Mezna M; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Pannifer A; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Paul NR; Cell Migration Laboratory, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Machesky L; Cell Migration Laboratory, CRUK Beatson Institute, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, G61 1QH Glasgow, UK.
  • McKinnon H; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Bower J; Drug Discovery Unit, CRUK Beatson Institute, Glasgow G61 1BD, UK.
Bioorg Med Chem Lett ; 29(8): 1023-1029, 2019 04 15.
Article em En | MEDLINE | ID: mdl-30773430
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Piridinas / Desenho de Fármacos / Proteínas de Transporte / Quinolonas / Proteínas dos Microfilamentos / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Piridinas / Desenho de Fármacos / Proteínas de Transporte / Quinolonas / Proteínas dos Microfilamentos / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article