Challenge model of TNF<sub>&#945;</sub> turnover at varying LPS and drug provocations.

Held, Felix; Hoppe, Edmund; Cvijovic, Marija; Jirstrand, Mats; Gabrielsson, Johan

Challenge model of TNF_α turnover at varying LPS and drug provocations.

Held, Felix; Hoppe, Edmund; Cvijovic, Marija; Jirstrand, Mats; Gabrielsson, Johan.

Afiliação

Held F; Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg, Sweden. felix.held@chalmers.se.
Hoppe E; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. felix.held@chalmers.se.
Cvijovic M; Grünenthal GmbH, Aachen, Germany.
Jirstrand M; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden.
Gabrielsson J; Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg, Sweden.

J Pharmacokinet Pharmacodyn ; 46(3): 223-240, 2019 06.

Article em En | MEDLINE | ID: mdl-30778719

Assuntos

Fator de Necrose Tumoral alfa/metabolismo; Animais; Biomarcadores/metabolismo; Lipopolissacarídeos/farmacologia; Masculino; Modelos Biológicos; Ratos; Ratos Sprague-Dawley

Palavras-chave

Challenge tests; Experimental design; Kinetic-dynamic modelling; Non-linear mixed effects modelling; Target biology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharmacokinet Pharmacodyn Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suécia

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