Impact of access to novel therapies on the initial management of castrate-resistant prostate cancer: an Australian multicentre study.
Intern Med J
; 49(11): 1378-1385, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-30779277
ABSTRACT
BACKGROUND:
The impact of regulatory approvals of new therapies for castration-resistant prostate cancer (CRPC) in Australia is unclear.AIMS:
To determine if changes in novel therapy access in Australia affected how clinicians initially managed men with newly diagnosed CRPC.METHODS:
Data from patients diagnosed with CRPC from 2013 to 2016 across three Australian hospitals were retrospectively collected. Baseline clinicopathological factors and initial management decision at the time of CRPC development (early treatment (ET) vs deferred treatment (DT)) were recorded. Categorical variables between cohorts were compared by Chi-squared analysis. Cox regression analysis was performed to assess the impact of CRPC diagnosis year on time to commencing life-prolonging systemic treatment (TTT).RESULTS:
Our study identified 137 CRPC patients, with 126 (92%) patients receiving life-prolonging systemic treatment. The median age was 73 years. The initial management decision was DT in 71 (52%) patients and ET in 66 (48%) patients. There was a significant shift from DT to ET during the study period (2013-2014 DT 61% vs ET 33%; 2015-2016 DT 39% vs ET 67%; P = 0.004), with a rise in novel androgen receptor signalling inhibitor use and simultaneous reduction in first-generation antiandrogen use at CRPC development. Each successive CRPC diagnosis year was associated with shorter TTT on univariate analysis (HR 1.5, 95% CI 1.3-1.7, P < 0.001).CONCLUSION:
Over time, clinicians are favouring earlier introduction of life-prolonging systemic treatment at the development of CRPC. This trend is largely driven by substantial uptake of novel androgen receptor signalling inhibitors as the preferred initial treatment for CRPC patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antagonistas de Receptores de Andrógenos
/
Neoplasias de Próstata Resistentes à Castração
/
Antagonistas de Androgênios
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Oceania
Idioma:
En
Revista:
Intern Med J
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália