Identification of residues critical for topology inversion of the transmembrane protein TM4SF20 through regulated alternative translocation.

Wang, Jingcheng; Kinch, Lisa N; Denard, Bray; Lee, Ching-En; Esmaeilzadeh Gharehdaghi, Elina; Grishin, Nick; Ye, Jin

Wang, Jingcheng; Kinch, Lisa N; Denard, Bray; Lee, Ching-En; Esmaeilzadeh Gharehdaghi, Elina; Grishin, Nick; Ye, Jin.

Afiliação

Wang J; From the Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Kinch LN; Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Denard B; From the Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Lee CE; From the Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Esmaeilzadeh Gharehdaghi E; From the Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Grishin N; Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Ye J; From the Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390. Electronic address: Jin.Ye@UTSouthwestern.edu.

J Biol Chem ; 294(15): 6054-6061, 2019 04 12.

Article em En | MEDLINE | ID: mdl-30808712

Assuntos

Tetraspaninas; Células A549; Motivos de Aminoácidos; Substituição de Aminoácidos; Humanos; Glicoproteínas de Membrana/química; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/metabolismo; Mutagênese Sítio-Dirigida; Mutação de Sentido Incorreto; Transporte Proteico; Proteínas Recombinantes de Fusão/química; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/metabolismo; Tetraspaninas/química; Tetraspaninas/genética; Tetraspaninas/metabolismo

Palavras-chave

TM4SF20; Topology; ceramide; membrane protein; protein chimera; protein translocation; transmembrane domain

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetraspaninas Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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