Inhibition of RhoA/ROCK signaling pathway ameliorates hypoxic pulmonary hypertension via HIF-1&#945;-dependent functional TRPC channels.

Wang, Xue-Ying; Mo, Dan; Tian, Wen; Liu, Xiao-Xiao; Zhou, Ya-Guang; Sun, Yang; Feng, Ying-Da; Xiao, Xiong; Hao, Xiao-Wei; Zhang, Hui-Nan; Li, Chen; Cao, Wei; Li, Xiao-Qiang

Inhibition of RhoA/ROCK signaling pathway ameliorates hypoxic pulmonary hypertension via HIF-1α-dependent functional TRPC channels.

Wang, Xue-Ying; Mo, Dan; Tian, Wen; Liu, Xiao-Xiao; Zhou, Ya-Guang; Sun, Yang; Feng, Ying-Da; Xiao, Xiong; Hao, Xiao-Wei; Zhang, Hui-Nan; Li, Chen; Cao, Wei; Li, Xiao-Qiang.

Afiliação

Wang XY; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Mo D; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Tian W; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Liu XX; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Zhou YG; Department of Physiology, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China.
Sun Y; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Feng YD; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Xiao X; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Hao XW; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Zhang HN; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Li C; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Cao W; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China; School of Chemistry & Pharmacy, Northwest A&F University, Y
Li XQ; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China. Electronic address: xxqqli@fmmu.edu.cn.

Toxicol Appl Pharmacol ; 369: 60-72, 2019 04 15.

Article em En | MEDLINE | ID: mdl-30831131

Assuntos

1-(5-Isoquinolinasulfonil)-2-Metilpiperazina/análogos & derivados; Amidas/farmacologia; Anti-Hipertensivos/farmacologia; Pressão Arterial/efeitos dos fármacos; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Músculo Liso Vascular/efeitos dos fármacos; Miócitos de Músculo Liso/efeitos dos fármacos; Inibidores de Proteínas Quinases/farmacologia; Hipertensão Arterial Pulmonar/prevenção & controle; Piridinas/farmacologia; Canais de Cátion TRPC/metabolismo; Quinases Associadas a rho/antagonistas & inibidores; Proteína rhoA de Ligação ao GTP/metabolismo; 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina/farmacologia; Animais; Sinalização do Cálcio; Linhagem Celular; Modelos Animais de Doenças; Hipóxia/complicações; Hipóxia/enzimologia; Hipóxia/fisiopatologia; Masculino; Camundongos Endogâmicos BALB C; Músculo Liso Vascular/enzimologia; Músculo Liso Vascular/fisiopatologia; Miócitos de Músculo Liso/enzimologia; Hipertensão Arterial Pulmonar/enzimologia; Hipertensão Arterial Pulmonar/etiologia; Hipertensão Arterial Pulmonar/fisiopatologia; Artéria Pulmonar/efeitos dos fármacos; Artéria Pulmonar/enzimologia; Artéria Pulmonar/fisiopatologia; Canais de Cátion TRPC/genética; Canal de Cátion TRPC6/genética; Canal de Cátion TRPC6/metabolismo; Vasoconstrição/efeitos dos fármacos; Quinases Associadas a rho/metabolismo; Proteína rhoA de Ligação ao GTP/genética

Palavras-chave

HIF-1α; Hypoxic pulmonary hypertension; Rho-kinase; RhoA; TRPC channels

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina / Proteína rhoA de Ligação ao GTP / Miócitos de Músculo Liso / Inibidores de Proteínas Quinases / Canais de Cátion TRPC / Subunidade alfa do Fator 1 Induzível por Hipóxia / Quinases Associadas a rho / Pressão Arterial / Amidas Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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