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Serum Testosterone 60 Months after Passive-Scatter Proton Therapy for Localized Prostate Cancer.
Nichols, R Charles; Morris, Christopher G; Bryant, Curtis; Hoppe, Bradford S; Henderson, Randal H; Mendenhall, William M; Li, Zuofeng; Costa, Joseph A; Williams, Christopher R; Mendenhall, Nancy P.
Afiliação
  • Nichols RC; a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , Florida , USA.
  • Morris CG; b University of Florida Health Proton Therapy Institute , Jacksonville , Florida , USA.
  • Bryant C; a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , Florida , USA.
  • Hoppe BS; b University of Florida Health Proton Therapy Institute , Jacksonville , Florida , USA.
  • Henderson RH; a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , Florida , USA.
  • Mendenhall WM; b University of Florida Health Proton Therapy Institute , Jacksonville , Florida , USA.
  • Li Z; a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , Florida , USA.
  • Costa JA; b University of Florida Health Proton Therapy Institute , Jacksonville , Florida , USA.
  • Williams CR; a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , Florida , USA.
  • Mendenhall NP; b University of Florida Health Proton Therapy Institute , Jacksonville , Florida , USA.
Cancer Invest ; 37(2): 85-89, 2019.
Article em En | MEDLINE | ID: mdl-30836776
ABSTRACT
Studies demonstrate a decline of ∼10% in serum testosterone (ST) level after X-ray radiotherapy for prostate cancer. We evaluated changes in ST for patients with low- and intermediate-risk prostate cancer receiving 70-82Gy(RBE) using passive-scatter proton therapy (PT). ST was checked at baseline (n = 358) and at 60+ months after PT (n = 166). The median baseline ST was 363.3 ng/dl (range, 82.0-974.0). The median ST 5 years after PT was 391.5 ng/dl (range, 108.0-1061.0). The difference was not statistically significant (p = 0.9341). Passive-scatter PT was not associated with testosterone suppression at 5 years, suggesting that protons may cause less out-of-field scatter radiation than X-rays.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Testosterona Limite: Humans / Male Idioma: En Revista: Cancer Invest Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Testosterona Limite: Humans / Male Idioma: En Revista: Cancer Invest Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos