A One-Pot Ring-Opening/Ring-Closure Sequence for the Synthesis of Polycyclic Spirooxindoles.

Ren, Ji-Wei; Zhao, Qing-Lan; Xiao, Jun-An; Xia, Peng-Ju; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua

Ren, Ji-Wei; Zhao, Qing-Lan; Xiao, Jun-An; Xia, Peng-Ju; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua.

Afiliação

Ren JW; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P.R. China.
Zhao QL; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P.R. China.
Xiao JA; College of Chemistry and Materials Science, Nanning Normal University, Nanning, 530001, Guangxi, P.R. China.
Xia PJ; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P.R. China.
Xiang HY; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P.R. China.
Chen XQ; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P.R. China.
Yang H; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P.R. China.

Chemistry ; 25(18): 4673-4677, 2019 Mar 27.

Article em En | MEDLINE | ID: mdl-30840339

ABSTRACT

ABSTRACT

One-pot ring-opening/ring-closure process of combining methyleneindolinone with 3-aminooxindole has been developed in this work. Novel polycyclic spirooxindoles were efficiently assembled under mild conditions in high yields (up to 95 %) with moderate to good diastereoselectivities (up to >955âd.r.) through simple filtration.

Palavras-chave

3-aminooxindole; methyleneindolinone; one-pot synthesis; polycyclic spirooxindole; ring-opening reactions

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article

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