Commensal Staphylococci Influence Staphylococcus aureus Skin Colonization and Disease.
Trends Microbiol
; 27(6): 497-507, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30846311
ABSTRACT
Commensal organisms that constitute the skin microbiota play a pivotal role in the orchestration of cutaneous homeostasis and immune competence. This balance can be promptly offset by the expansion of the opportunistic pathogen Staphylococcus aureus, which is responsible for the majority of bacterial skin infections. S. aureus carriage is also known to be a precondition for its transmission and pathogenesis. Recent reports suggest that skin-dwelling coagulase-negative staphylococci (CoNS) can prime the skin immune system to limit the colonization potential of invaders, and they can directly compete through production of antimicrobial molecules or through signaling antagonism. We review recent advances in these CoNS colonization resistance mechanisms, which may serve to aid development of pharmacologic and probiotic intervention strategies to limit S. aureus skin colonization and disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
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Staphylococcus
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Staphylococcus aureus
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Infecções Cutâneas Estafilocócicas
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Interações Hospedeiro-Patógeno
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Interações Microbianas
Limite:
Humans
Idioma:
En
Revista:
Trends Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos