Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in <i>KRAS</i>-Mutant Pancreatic and Colorectal Cancer.

Weisner, Jörn; Landel, Ina; Reintjes, Christoph; Uhlenbrock, Niklas; Trajkovic-Arsic, Marija; Dienstbier, Niklas; Hardick, Julia; Ladigan, Swetlana; Lindemann, Marius; Smith, Steven; Quambusch, Lena; Scheinpflug, Rebekka; Depta, Laura; Gontla, Rajesh; Unger, Anke; Müller, Heiko; Baumann, Matthias; Schultz-Fademrecht, Carsten; Günther, Georgia; Maghnouj, Abdelouahid; Müller, Matthias P; Pohl, Michael; Teschendorf, Christian; Wolters, Heiner; Viebahn, Richard; Tannapfel, Andrea; Uhl, Waldemar; Hengstler, Jan G; Hahn, Stephan A; Siveke, Jens T; Rauh, Daniel

Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer.

Weisner, Jörn; Landel, Ina; Reintjes, Christoph; Uhlenbrock, Niklas; Trajkovic-Arsic, Marija; Dienstbier, Niklas; Hardick, Julia; Ladigan, Swetlana; Lindemann, Marius; Smith, Steven; Quambusch, Lena; Scheinpflug, Rebekka; Depta, Laura; Gontla, Rajesh; Unger, Anke; Müller, Heiko; Baumann, Matthias; Schultz-Fademrecht, Carsten; Günther, Georgia; Maghnouj, Abdelouahid; Müller, Matthias P; Pohl, Michael; Teschendorf, Christian; Wolters, Heiner; Viebahn, Richard; Tannapfel, Andrea; Uhl, Waldemar; Hengstler, Jan G; Hahn, Stephan A; Siveke, Jens T; Rauh, Daniel.

Afiliação

Weisner J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Landel I; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Reintjes C; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Uhlenbrock N; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Trajkovic-Arsic M; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.
Dienstbier N; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Hardick J; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Ladigan S; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lindemann M; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), partner site Essen, West German Cancer Center, University Hospital Essen, Essen, Germany.
Smith S; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Quambusch L; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), partner site Essen, West German Cancer Center, University Hospital Essen, Essen, Germany.
Scheinpflug R; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Depta L; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Gontla R; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.
Unger A; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Müller H; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Baumann M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Schultz-Fademrecht C; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Günther G; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Maghnouj A; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Müller MP; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Pohl M; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Teschendorf C; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Wolters H; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Viebahn R; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Tannapfel A; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Uhl W; Lead Discovery Center GmbH, Dortmund, Germany.
Hengstler JG; Lead Discovery Center GmbH, Dortmund, Germany.
Hahn SA; Lead Discovery Center GmbH, Dortmund, Germany.
Siveke JT; Lead Discovery Center GmbH, Dortmund, Germany.
Rauh D; Leibniz Research Centre for Working Environment and Human Factors (IfADo), TU Dortmund University, Dortmund, Germany.

Cancer Res ; 79(9): 2367-2378, 2019 05 01.

Article em En | MEDLINE | ID: mdl-30858154

Assuntos

Antineoplásicos/farmacologia; Neoplasias Colorretais/tratamento farmacológico; Mutação; Neoplasias Pancreáticas/tratamento farmacológico; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Proteínas Proto-Oncogênicas p21(ras)/genética; Piridonas/farmacologia; Pirimidinonas/farmacologia; Animais; Apoptose; Ciclo Celular; Proliferação de Células; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Quimioterapia Combinada; Feminino; Humanos; Camundongos; Camundongos Nus; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Neoplasias Pancreáticas/patologia; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Piridonas / Pirimidinonas / Neoplasias Colorretais / Proteínas Proto-Oncogênicas p21(ras) / Proteínas Proto-Oncogênicas c-akt / Mutação / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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