Influence of LRP5 (rs556442) polymorphism on insulin resistance in healthy Iranian children and adolescents
Turk J Med Sci
; 49(2): 490-496, 2019 04 18.
Article
em En
| MEDLINE
| ID: mdl-30866603
ABSTRACT
Background/aim:
Genetic aspects play a role in insulin resistance in children. In this study, for the first time, the association of LRP5 (rs556442) polymorphism and insulin resistance in Iranian children and adolescents was investigated. Materials andmethods:
The study population comprises children and adolescents aged 918 years. Anthropometric and biochemical parameters were assessed. Insulin resistance/sensitivity was determined by the quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment-insulin resistance (HOMA-IR), insulin-to-glucose ratio, McAuley index, revised McAuley index, fasting insulin resistance index (FIRI), and Bennett's index. LRP5 (rs566442) single nucleotide polymorphism (SNP) was identified using restriction fragment length polymorphism (RFLP). Linear regression analysis was used to determine the association between the LRP5 polymorphism (rs556442) and insulin sensitivity indexes.Results:
Significant differences were found between GG genotype vs. AG/AA genotypes for McAuley index (P = 0.049) and revised McAuley index (P = 0.044) when adjusted for interaction factors (age, sex, and puberty) in regression models. No significant association was found between LRP5 (rs566442) and other insulin resistance indexes. Also, LRP5 (rs566442) did not show a significant impact on biochemical parameters.Conclusion:
This study showed that LRP5 polymorphism (rs556442) was associated with insulin resistance in Iranian children and adolescents.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Polimorfismo de Nucleotídeo Único
/
Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Turk J Med Sci
Ano de publicação:
2019
Tipo de documento:
Article