Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function.

Jones, Dallas; Como, Christina N; Jing, Lichen; Blackmon, Anna; Neff, Charles Preston; Krueger, Owen; Bubak, Andrew N; Palmer, Brent E; Koelle, David M; Nagel, Maria A

Jones, Dallas; Como, Christina N; Jing, Lichen; Blackmon, Anna; Neff, Charles Preston; Krueger, Owen; Bubak, Andrew N; Palmer, Brent E; Koelle, David M; Nagel, Maria A.

Afiliação

Jones D; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Como CN; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Jing L; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Blackmon A; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Neff CP; Department of Medicine, Division of Allergy and Clinical Immunology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Krueger O; Department of Medicine, Division of Allergy and Clinical Immunology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Bubak AN; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Palmer BE; Department of Medicine, Division of Allergy and Clinical Immunology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Koelle DM; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Nagel MA; Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America.

PLoS Pathog ; 15(3): e1007650, 2019 03.

Article em En | MEDLINE | ID: mdl-30870532

Assuntos

Antígeno B7-H1/genética; Linfócitos T CD8-Positivos/metabolismo; Herpesvirus Humano 3/metabolismo; Anticorpos Antivirais; Antígenos CD; Antígeno B7-H1/imunologia; Antígeno B7-H1/metabolismo; Linfócitos T CD4-Positivos; Antígeno CTLA-4; Técnicas de Cocultura; Regulação da Expressão Gênica; Receptor Celular 2 do Vírus da Hepatite A; Herpes Zoster/metabolismo; Herpes Zoster/virologia; Herpesvirus Humano 3/patogenicidade; Humanos; Leucócitos Mononucleares/metabolismo; Leucócitos Mononucleares/virologia; Proteína 2 Ligante de Morte Celular Programada 1; Receptor de Morte Celular Programada 1; Viroses; Proteína do Gene 3 de Ativação de Linfócitos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Herpesvirus Humano 3 / Linfócitos T CD8-Positivos / Antígeno B7-H1 Limite: Humans Idioma: En Revista: PLoS Pathog Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google