Low dose Rituximab for pre-emptive treatment of Epstein Barr virus reactivation after allogenic hematopoietic stem cell transplantation.
Curr Res Transl Med
; 67(4): 145-148, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-30871955
ABSTRACT
INTRODUCTION:
The most used preemptive therapy for Epstein Barr virus reactivation post allogeneic hematopoietic stem cell (HSCT) transplant is Rituximab, 375 mg/m2, once weekly until EBV viremia negativity. There is no data suggesting such a high dose.OBJECTIVE:
We hypothesized that a lower dose of Rituximab would be as efficient with less toxicity. PATIENTS In a retrospective, monocentric study, we analyzed 16 consecutive patients treated preemptively with low dose Rituximab for EBV reactivation post HSCT. Patients were treated with low Rituximab dose of 100 mg/m² weekly. Success was defined by a decrease of EBV viremia of 1 log10 and below 1000 UI/ml, and the absence of post-transplant lymphoproliferative disorder (PTLD).RESULTS:
Success rate was 93.4% (15/16). One (1/16, 6%) PTLD was diagnosed after preemptive therapy, despite a negative viremia.CONCLUSION:
A low dose of Rituximab of 100 mg/m² per injection for pre-emptive therapy of EBV reactivation post HSCT is safe and effective for preventing PTLD. Prospective, randomized, multicentric trials with larger number of patient are needed to determine the best rituximab dose.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Viral
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Herpesvirus Humano 4
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Transplante de Células-Tronco Hematopoéticas
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Quimioprevenção
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Neoplasias Hematológicas
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Infecções por Vírus Epstein-Barr
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Rituximab
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Curr Res Transl Med
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
França