Pulmonary Mycobacterium abscessus complex in children with cystic fibrosis: A practical management guideline.
J Paediatr Child Health
; 55(5): 502-511, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30884016
ABSTRACT
The treatment of Mycobacterium abscessus complex (MABSC) pulmonary infections is an emerging challenge in patients with cystic fibrosis (CF). Multidrug therapy for prolonged durations is required and carries the significant burden of drug-related toxicity, cost and selective pressure for multiresistant bacteria. International guidelines acknowledge that clinical and in vitro data to support treatment regimens are limited, particularly in children. As part of a collaboration between the infectious diseases and respiratory units at our institution, we have developed a modified treatment guideline that aims to balance the aims of MABSC eradication and slowing disease progression with minimising drug toxicity and resistance. The outcomes of this treatment approach will be monitored and reported. In this manuscript, we discuss the available evidence for treatment choices and present our treatment guideline for paediatric patients with CF and MABSC infection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrose Cística
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Mycobacterium abscessus
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Antibacterianos
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Infecções por Mycobacterium não Tuberculosas
Tipo de estudo:
Diagnostic_studies
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Guideline
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Prognostic_studies
Limite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
J Paediatr Child Health
Assunto da revista:
PEDIATRIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália