Dissecting the Toxic Effects of Zika Virus Proteins on Neural Progenitor Cells.

Ferreira, Raiane O; Garcez, Patricia P

Ferreira, Raiane O; Garcez, Patricia P.

Afiliação

Ferreira RO; Institute of Biomedical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Garcez PP; Institute of Biomedical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: ppgarcez@icb.ufrj.br.

Neuron ; 101(6): 989-991, 2019 03 20.

Article em En | MEDLINE | ID: mdl-30897362

ABSTRACT

ABSTRACT

The mechanisms by which Zika virus (ZIKV) disrupts neurogenesis and causes microcephaly are poorly understood. In this issue of Neuron, Li et al. (2019) demonstrate that ZIKV protease NS2B-NS3 heterodimers cleave Septin-2 and lead to cytokinesis defects.

Assuntos

Microcefalia; Células-Tronco Neurais; Infecção por Zika virus; Zika virus; Humanos; Septinas

Palavras-chave

Zika virus; brain malformation; congenital Zika syndrome; cytokinesis; microcephaly; neural stem cells; pathogenesis; septin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neurais / Zika virus / Infecção por Zika virus / Microcefalia Limite: Humans Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil

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