Parkinson's disease patients experiencing peak-dose dyskinesia redistribute involuntary movements throughout their body to improve motor control.
Parkinsonism Relat Disord
; 64: 312-314, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-30935827
ABSTRACT
INTRODUCTION:
In Parkinson's disease (PD), dyskinesia is considered a major side effect of dopamine replacement therapy. Nevertheless, many patients with dyskinesia function adequately.OBJECTIVE:
To study objectively dyskinesia phenomenology in order to understand why or how patients with dyskinesia are still able to perform motor tasks.METHODS:
Patients with and without dyskinesia, as well as healthy older adults, performed a geostationary task during which they attempted to stabilize a glass of water at eye level. Dyskinesia amplitude displayed by each body segment was extracted from accelerometers, and its distribution among the segments, analyzed.RESULTS:
Patients experiencing dyskinesia initially distributed most of their dyskinesia away from the segments directly involved in the task. With time, this distribution shifts back towards the hand.CONCLUSION:
Our results suggest that patients developed a strategy of involuntary movement's redistribution to attenuate their functional impact on voluntary movements. However, this strategy can only be maintained for a certain period before "re-emerging" dyskinesia occurs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Desempenho Psicomotor
/
Discinesia Induzida por Medicamentos
/
Atividade Motora
/
Antiparkinsonianos
Tipo de estudo:
Qualitative_research
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Parkinsonism Relat Disord
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article